AI Article Synopsis
- The transcription factor SKN-1 is essential for several biological processes, including development, immune responses, and lifespan regulation in the organism.
- This study focuses on the SKN-1 c isoform, investigating its specific role in development through the creation of mutants with targeted mutations in SKN-1 isoforms.
- Findings indicate that SKN-1 c is critical for embryonic development, as mutants lacking it resulted in inviable embryos, whereas those with other SKN-1 isoforms developed normally.
Article Abstract
The transcription factor SKN-1 in is a critical regulator of various biological processes, impacting development, diet and immune responses, cellular detoxification, and lipid metabolism; thereby playing a pivotal role in regulating the health and lifespan of the organism. The primary isoforms of SKN-1 ( SKN-1 a, SKN-1 b, and SKN-1 c) exhibit distinct functions resembling mammalian Nrf transcription factors. This study investigates the specific role of the SKN-1 c isoform in development by generating mutants with targeted missense mutations in the and isoforms. The mutants, which replaces a start methionine with alanine, renders SKN-1 c non-functional while preserving other isoforms, produced inviable embryos, requiring a balancer chromosome for proper embryonic development. In contrast, mutants, which replaces the start methionine with alanine for this isoform, displayed normal embryonic development and hatching. Moreover, the data suggest that SKN-1 c plays a crucial role in embryonic development, as strains without maternally deposited SKN-1 c lead to embryos that are developmentally arrested. Together, these findings contribute to our understanding of SKN-1 c's specific role in influencing embryogenesis and development in
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11255869 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.001205 | DOI Listing |
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