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| http://dx.doi.org/10.18240/ijo.2024.07.24 | DOI Listing |
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A case of herpesviral corneal endotheliitis presenting with corneal endothelial defect.
Int J Ophthalmol
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Department of Ophthamology, Zhujiang Hosptial, Southern Medical University, Guangzhou 510280, Guangdong Province, China.
NOVEL (SIMPLEXVIRUS DOLICHOTINEALPHA1) ASSOCIATED WITH FATALITY IN FOUR PATAGONIAN MARA ().
J Zoo Wildl Med
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Department of Comparative, Diagnostic & Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA.
Four of seven Patagonian maras () at a zoological institution developed acute neurologic signs that progressed to tetraparesis and death. All affected were young adult females (10 mon-5 yr old) that presented over 11 d. Clinical signs were rapidly progressive and unresponsive to supportive therapies.
View Article and Find Full Text PDFDetection of macropodid alphaherpesvirus 2 infection and lesions in sudden death of a captive Virginia opossum and a water opossum.
J Vet Diagn Invest
July 2024
California Animal Health & Food Safety Laboratory System (CAHFS), University of California, Davis, CA, USA.
Article Synopsis
- Macropodid alphaherpesvirus 2 (MaAHV2) has been linked to outbreaks in captive marsupials in Australia and is observed for the first time in Virginia and water opossums.
- Both opossums showed severe liver and lung damage, along with signs of sepsis, leading to their deaths within weeks.
- Genetic testing revealed that the herpesvirus found in the opossums was over 99% identical to MaAHV2, suggesting that these species can become infected, which raises concerns for zoos with mixed-species animal populations.
Identification of asinine gamma herpesviruses in a donkey with interstitial pulmonary fibrosis, pleural effusion and thrombocytopenia.
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Department of Veterinary Medical Sciences (DIMEVET), University of Bologna, Via Tolara di Sopra, 50, 40064 Ozzano dell'Emilia, Bologna, Italy.
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View Article and Find Full Text PDFViral codon optimization on SARS-CoV-2 Spike boosts immunity in the development of COVID-19 mRNA vaccines.
J Med Virol
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Department of Cancer Biology and Infection Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Life-long persistent herpesviruses carry "trans-inducers" to overcome the unusual codon usage of their glycoproteins for efficient expression. Strikingly, this "trans-inducibility" can be achieved by simply changing the codon-usage of acute virus glycoproteins to that of persistent herpesvirus glycoproteins with herpesviral trans-inducer. Here, we apply the "persistent viral codon-usage-trans-inducer" principle to SARS-CoV-2 Spike mRNA vaccine platform, in which the codon-usage of Spike is changed to that of Herpes Simplex Virus-1 (HSV-1) glycoprotein B (gB) with its "trans-inducer" ICP27.
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