Lysergic acid diethylamide (LSD) is a synthetic psychedelic compound with potential therapeutic value for psychiatric disorders. This study aims to establish Caenorhabditis elegans as an in vivo model for examining LSD's effects on locomotor behavior. Our results demonstrate that LSD is absorbed by C. elegans and that the acute treatment reduces animal speed, similar to the role of endogenous serotonin. This response is mediated in part by the serotonergic receptors SER-1 and SER-4. Our findings highlight the potential of this nematode as a new experimental model in psychedelic research.
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| http://dx.doi.org/10.1016/j.neulet.2024.137903 | DOI Listing |
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Article Synopsis
- Serotonergic psychedelics, like LSD and psilocybin, alter consciousness and may help treat mental health issues, but how they work is still not entirely clear.
- The study reviews subjective experiences, neuroimaging, and molecular actions, indicating LSD leads to more intense visionary experiences compared to psilocybin and alters brain connectivity patterns.
- Findings suggest a complex relationship between different psychedelics' effects and highlight the need for standardized research methods to better understand these substances and their therapeutic potential.*
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