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An open-source SQL database schema for integrated clinical and translational data management in clinical trials.
Clin Trials
December 2024
Cancer Research UK Southampton Clinical Trials Unit, MP131, Southampton General Hospital, University of Southampton, Southampton, UK.
Unlocking the power of personalised medicine in oncology hinges on the integration of clinical trial data with translational data (i.e. biospecimen-derived molecular information).
View Article and Find Full Text PDFTranslating CD47-targeted therapy in gastrointestinal cancers: Insights from preclinical to clinical studies.
iScience
December 2024
Department of General Surgery, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou 350001, People's Republic of China.
This review presents a thorough investigation of the role of CD47 in gastrointestinal cancers. We performed a comprehensive, in-depth review of over 100 preclinical and clinical studies focused on inhibiting CD47. The research highlights the potential of targeted CD47 to enhance existing treatments by boosting the immune response to cancer cells.
View Article and Find Full Text PDFAllelopathic influence of usnic acid on Physcomitrium patens: A proteomics approach.
Plant Physiol Biochem
December 2024
Department of Plant Biology, Pavol Jozef Šafárik University in Košice, Mánesova 1889/23, 040 01, Košice, Slovakia. Electronic address:
Allelopathy, the chemical interaction of plants by their secondary metabolites with surrounding organisms, profoundly influences their functional features. Lichens, symbiotic associations of fungi and algae and/or cyanobacteria, produce diverse secondary metabolites, among other usnic acid, which express to have potent biological activities. Mosses, i.
View Article and Find Full Text PDFMinimally invasive reduction of irreducible, sagittally unstable peritrochanteric fractures: Novel technique and early results.
Chin J Traumatol
December 2024
Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address:
Purpose: The management of irreducible, sagittally unstable peritrochanteric fractures presents a significant challenge due to the inability to achieve closed reduction using conventional techniques. This study introduces a novel minimally invasive technique leveraging the mechanical advantage principle with long, angled hemostatic clamps.
Methods: A retrospective review was performed on 16 patients who sustained sagittally unstable peritrochanteric fractures and underwent a percutaneous hemostatic clamp leverage reduction procedure.
Update on tick-borne rickettsioses in mainland Portugal: emerging threats and potential vectors.
Parasit Vectors
December 2024
Global Health and Tropical Medicine- Institute of Hygiene and Tropical Medicine, NOVA University of Lisbon, Rua da Junqueira 100, 1349-008, Lisbon, Portugal.
Background: Tick-borne rickettsioses (TBR) are emerging, neglected, zoonoses, caused by intracellular α-proteobacteria of the genus Rickettsia, that pose a growing public health concern. The aim of the present study was to evaluate rickettsial infections in questing ticks collected from four different ecological areas in mainland Portugal.
Methods: Over a two-year period, a total of 707 questing ticks were collected.
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