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Quantitative analysis of choroidal vascular structures and anatomical changes in pachychoroid spectrum diseases using ultra-widefield SS-OCTA.
Sci Rep
January 2025
The Department of Ophthalmology, General Hospital of Central Theater Command, No. 627 Wuluo Road, Wuchang District, Wuhan, 430000, Hubei, China.
This study used ultra-widefield swept-source optical coherence tomography angiography (UWF SS-OCTA) to analyze and compare choroidal blood flow and anatomical changes in eyes affected by central serous chorioretinopathy (CSC), pachychoroid neovasculopathy (PNV), and uncomplicated pachychoroid (UCP). The findings revealed distribution patterns of vortex veins across the three patient groups and provided initial findings insights into the origin of choroidal neovascularization (CNV) in PNV. A total of 44 patients with CSC, 38 with PNV, and 46 with UCP were included in the analysis.
View Article and Find Full Text PDFIn this case series of two patients, we discuss pachychoroid as a risk factor for predicting exudative retinal detachment (RD) after panretinal photocoagulation (PRP). The first patient was a 55-year-old diabetic male with unstable proliferative diabetic retinopathy (PDR), serous pigment epithelial detachment (PED), and pachychoroid confirmed via fluorescein angiography (FA) and optical coherence tomography (OCT), who underwent PRP. Post-PRP, the patient complained of visual loss in both eyes.
View Article and Find Full Text PDFImportance of fluorescein angiography as a predictor of treatment response in patients with pachychoroid neovasculopathy.
Sci Rep
November 2024
Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan.
The purpose of this study was to evaluate the treatment outcomes of patients with pachychoroid neovasculopathy (PNV) who received photodynamic therapy (PDT) combined with intravitreal anti-vascular endothelial growth factor (VEGF) agents, with a particular focus on the fluorescein angiography (FA) findings. We retrospectively studied 33 eyes of 32 consecutive treatment-naïve patients with PNV who were scheduled for PDT combined with anti-VEGF agents between November 2017 and May 2022, with a follow-up period of 1 year or longer. We classified patients into two groups: central serous chorioretinopathy (CSC)-dominant type and macular neovascularization (MNV)-dominant type based on the baseline FA findings.
View Article and Find Full Text PDFPredictive risk scores for visual prognosis after photodynamic therapy for central serous chorioretinopathy.
Graefes Arch Clin Exp Ophthalmol
November 2024
Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Purpose: To comprehensively evaluate baseline characteristics of patients with central serous chorioretinopathy (CSC) and develop predictive risk scores to identify visual prognosis.
Methods: This single-institute, retrospective cohort study included 144 eyes of 144 patients with CSC who underwent photodynamic therapy and achieved serous retinal detachment resolution. We developed and assessed the performance of several risk scores for best-corrected visual acuity (BCVA) outcomes six months post-treatment: i) BCVA improvement (≤-1.
Asymmetric choroidal vascular pattern in tilted disc syndrome.
Graefes Arch Clin Exp Ophthalmol
November 2024
Department of Ophthalmology, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.
Purpose: To observe the choroidal vasculature in patients with tilted disc syndrome (TDS) using en face optical coherence tomography (OCT) and to evaluate the symmetry of the choroidal vascular pattern in the macular area.
Methods: En face OCT was performed using a Plex Elite 9000 (Zeiss) with a 12 × 12 mm image of the macula, which was flattened with retinal pigment epithelium and segmented into choroidal layers. The middle/large choroidal vessels were evaluated for vertical symmetry qualitatively by the retina specialist coauthors and quantitatively by binarization analysis of choroidal vessel density and mean vessel diameter.
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