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Reduced Expression of Oligodendrocyte Linage-Enriched Transcripts During the Endoplasmic Reticulum Stress/Integrated Stress Response. | LitMetric

AI Article Synopsis

  • Endoplasmic reticulum (ER) stress in oligodendrocyte lineage cells is linked to various central nervous system diseases, including traumatic spinal cord injury and multiple sclerosis.
  • RNA sequencing of rat oligodendrocyte precursor cells revealed that ER stress drugs thapsigargin and tunicamycin upregulate stress response genes, with tunicamycin showing a stronger effect on ER stress markers.
  • Both drugs led to a reduction in genes associated with oligodendrocyte identity and proliferation, indicating that prolonged ER stress may contribute to myelin degeneration and dysfunction in related pathologies.

Article Abstract

Endoplasmic reticulum (ER) stress in oligodendrocyte (OL) linage cells contributes to several CNS pathologies including traumatic spinal cord injury (SCI) and multiple sclerosis. Therefore, primary rat OL precursor cell (OPC) transcriptomes were analyzed using RNASeq after treatments with two ER stress-inducing drugs, thapsigargin (TG) or tunicamycin (TM). Gene ontology term (GO) enrichment showed that both drugs upregulated mRNAs associated with the general stress response. The GOs related to ER stress were only enriched for TM-upregulated mRNAs, suggesting greater ER stress selectivity of TM. Both TG and TM downregulated cell cycle/cell proliferation-associated transcripts, indicating the anti-proliferative effects of ER stress. Interestingly, many OL lineage-enriched mRNAs were downregulated, including those for transcription factors that drive OL identity such as . Moreover, ER stress-associated decreases of OL-specific gene expression were found in mature OLs from mouse models of white matter pathologies including contusive SCI, toxin-induced demyelination, and Alzheimer's disease-like neurodegeneration. Taken together, the disrupted transcriptomic fingerprint of OL lineage cells may facilitate myelin degeneration and/or dysfunction when pathological ER stress persists in OL lineage cells.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262469PMC
http://dx.doi.org/10.1080/17590914.2024.2371162DOI Listing

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