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Aesthetic Reconstruction of Huge Full-Thickness Defection of Lower Eyelid Using Nasolabial Mucosal-Myocutaneous Propeller Flap.
J Craniofac Surg
January 2025
Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Reconstruction after the excision of a lower eyelid tumor should be focused on the restoration of both functionality and aesthetic appeal. Accurate identification and appropriate intervention are crucial for the favorable resolution of the condition. This technique used a nasolabial mucosal-myocutaneous propeller flap to reconstruct a huge full-thickness defection of right lower eyelid because of basal cell carcinoma.
View Article and Find Full Text PDFComparative genetic analysis of blood and semen samples in sperm donors from Hunan, China.
Ann Med
December 2025
Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive & Genetic Hospital of International Trust and Investment Corporation (CITIC)-Xiangya, Changsha, China.
Objectives: At present, most genetic tests or carrier screening are performed with blood samples, and the known carrier rate of disease-causing variants is also derived from blood. For semen donors, what is really passed on to offspring is the pathogenic variant in their sperm. This study aimed to determine whether pathogenic variants identified in the sperm of young semen donors are also present in their blood, and whether matching results for blood are consistent with results for sperm.
View Article and Find Full Text PDFNovel conditioning and prophylaxis regimens for relapse prevention.
Hematology Am Soc Hematol Educ Program
December 2024
Division of Hematology, Department of Medicine and Surgery, University of Perugia, Italy.
Article Synopsis
- Recent advancements in hematopoietic cell transplantation (HCT) for leukemia have improved safety and patient outcomes through better conditioning regimens and graft-versus-host disease management.
- Despite these improvements, leukemia relapse remains a significant challenge, prompting research into its mechanisms and ways to enhance graft-versus-leukemia (GVL) effects.
- The review highlights criteria for selecting donors that boost GVL activity, innovative conditioning approaches to reduce disease burden, and strategies to manipulate grafts for effective antileukemic action while minimizing immune suppression.
Recent advances and future prospects in oxidative-reduction low-triggering-potential electrochemiluminescence strategies based on nanoparticle luminophores.
Analyst
December 2024
School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250100, China.
Article Synopsis
- - The oxidative-reduction electrochemiluminescence (ECL) potential is crucial for producing light while minimizing interference, ensuring electrode compatibility, and protecting biological molecules from damage.
- - Nanoparticle luminophores like quantum dots and metal nanoclusters show promise for ECL sensors due to their adjustable properties, but there's a lack of reviews focused on their use in low-triggering-potential (LTP) ECL systems.
- - This review highlights advances in LTP ECL strategies using nanoparticle luminophores, covering topics like matching coreactants, doping, and surface-engineering strategies, while also exploring future challenges and applications in bio-relevant contexts.
Understanding the Carbyne Formation from CH Complexes.
J Am Chem Soc
November 2024
Institute of Chemistry, Inorganic Chemistry, University of Graz, Schubertstrasse 1, 8010 Graz, Austria.
Nature chooses a high-valent tungsten center at the active site of the enzyme acetylene hydratase to facilitate acetylene hydration to acetaldehyde. However, the reactions of tungsten-coordinated acetylene are still not well understood, which prevents the development of sustainable bioinspired alkyne hydration catalysts. Here we report the reactivity of two bioinspired tungsten complexes with the acetylene ligand acting as a four-: [W(CO)(CH)(PymS)] () and a two-electron donor: [WO(CH)(PymS)] (), with PMe as a nucleophile to simulate the enzyme's reactivity (PymS = 4-(trifluoromethyl)-6-methylpyrimidine-2-thiolate).
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