Langerhans cell histiocytosis (LCH) is a rare clonal neoplasm derived from Langerhans-type cells that express CD 1a, langerin, and S 100 on immunohistochemistry. LCH usually involves multiple sites and multiple systems or multiple sites in a single system. Solitary LCH commonly involves the bones (especially the skull), lymph nodes, skin, and lungs. Solitary LCH of the thyroid is an extremely rare disease with a few reported cases in the indexed literature and poses a diagnostic dilemma for both the clinician and pathologist. Histopathology along with ancillary tests forms the gold standard for diagnosis. Surgical resection alone offers a good prognosis once multisystemic involvement has been ruled out. Herein is reported one such case of solitary LCH in a young male patient who remains disease-free after 2 years of follow-up.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4103/jcrt.jcrt_1376_22 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neuroimaging Spectrum of Erdheim-Chester Disease: An Image-based Review.
AJNR Am J Neuroradiol
November 2024
From the (1) Department of Radiology, Tata Memorial Hospital, Parel, Mumbai 400012 (P.R.), (2) Department of Radiology, Mayo Clinic, Rochester, MN (H.J.S, J.C.B, S.A.M, P.J.F, C.M.C, G.B.), and (3) Department of Radiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 55902 (N.S., A.A), and The authors have no relevant disclosures of interest.
Erdheim-Chester Disease (ECD) is a rare, multisystem histiocytic disorder characterized by its variable clinical presentations. Central Nervous System (CNS) involvement is observed in approximately half of ECD patients (up to 76% in some series), and often carries a poorer prognosis. While CNS involvement may remain asymptomatic, others may experience a range of neurological symptoms, including cognitive decline, neuropsychiatric disturbances, motor deficits, cranial or peripheral neuropathies, and endocrine abnormalities.
View Article and Find Full Text PDFOrbital Langerhans Cell Histiocytosis: A Systematic Review of 228 Cases.
Cureus
October 2024
Department of Surgery, Baghdad Teaching Hospital, Medical City Complex, Baghdad, IRQ.
Orbital Langerhans cell histiocytosis (LCH) is an extremely rare disorder, and widely different manifestations often make it diagnostically challenging. The variability of symptoms - from common presentations, such as eyelid swelling and exophthalmos, to very atypical symptoms, like headaches and diplopia - frequently results in delayed diagnosis and mismanagement. This systematic review aims to describe in detail the clinical presentation, diagnostic approaches, treatment modalities, and outcomes of orbital LCH.
View Article and Find Full Text PDFHistiocytic lesion masquerading as papillary carcinoma thyroid-A case report.
J Cancer Res Ther
April 2024
Department of Radio-Diagnosis, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.
Langerhans cell histiocytosis (LCH) is a rare clonal neoplasm derived from Langerhans-type cells that express CD 1a, langerin, and S 100 on immunohistochemistry. LCH usually involves multiple sites and multiple systems or multiple sites in a single system. Solitary LCH commonly involves the bones (especially the skull), lymph nodes, skin, and lungs.
View Article and Find Full Text PDFCase report: Uncommon manifestations of Rosai-Dorfman disease in the liver mimicking HCC.
Front Oncol
June 2024
Department of Pathology, Baoji Central Hospital, Baoji, China.
Rosai-Dorfman-Destombes disease (RDD) is a rare non-Langerhans cell histiocytosis (LCH) disorder characterized by systemic extranodal lesions. Common cases include skin lesions, whereas liver lesions are rare. This study presents a case of a 66-year-old woman with a solitary extranodal liver lesion who underwent successful surgical treatment followed by glucocorticoid therapy.
View Article and Find Full Text PDFPotential indication of chemotherapy for hypodipsia and arginine vasopressin deficiency secondary to hypothalamic-pituitary Langerhans cell histiocytosis: a case report and literature review.
Clin Pediatr Endocrinol
April 2024
Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.
Article Synopsis
- HP-LCH is linked to arginine vasopressin deficiency (AVD), but patients typically don’t show changes in their osmotic threshold for thirst (OTT).
- This case study presents a nine-year-old girl whose hypodipsia (reduced thirst) improved during chemotherapy for HP-LCH, allowing her to feel thirst at previously high serum sodium levels.
- The findings suggest that chemotherapy may help restore the body's thirst mechanisms in patients with AVD linked to HP-LCH, possibly by alleviating pressure on the hypothalamus.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!