The aim of current study is to explore the epigenetic changes and function of KCTD8 in human hepatocellular carcinoma (HCC). HCC cell lines and tissue samples were employed. Methylation specific PCR, flow cytometry, immunoprecipitation and xenograft mouse models were used. was methylated in 44.83% (104/232) of HCC and its methylation may act as an independent poor prognostic marker. KCTD8 expression was regulated by DNA methylation. KCTD8 suppressed HCC cell growth both and via inhibiting PI3K/AKT pathway. Methylation of is an independent poor prognostic marker, and epigenetic silencing of KCTD8 increases the malignant tendency in HCC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370965 | PMC |
| http://dx.doi.org/10.1080/17501911.2024.2370590 | DOI Listing |
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