Background: Posterior glenoid bone loss is frequently observed in patients with osteoarthritis undergoing reverse total shoulder arthroplasty. Glenoid bone loss can reduce the baseplate back support area and the number of screws for fixation. The purpose of this study is to determine how initial baseplate fixation is affected by biomechanical factors introduced by glenoid bone loss such as reduced baseplate back support area and reduced screw number using three-dimensional finite element analysis.
Methods: Computerized tomography images of a healthy shoulder were selected and segmented to obtain the solid geometry. Solid models were generated with 100%, 75%, 67%, 50%, and 25% glenoid baseplate back support. With these geometries, two groups of finite element models were then built. In the bone loss areas, screws were maintained in one group of models but were removed in the other group of models. 750N compressive loading was applied along the direction parallel to the scapula axis. Maximum von Mises stress and maximum micromotion between the bone and implant were recorded and evaluated for each glenoid bone model.
Results: In the group of models where all screws remained in place, the maximum stress and maximum micromotion between the bone and implant exhibited minimal variation. The maximum stresses were 21.10MPa and the maximum micromotions were between 2-3 μm. However, in the group of models removing screws in the bone loss areas, maximum stress increased from 20MPa to 45MPa and maximum micromotion increased from 2 μm to 85 μm as the backside support area decreased from 100% to 25%.
Discussion: In conclusion, this three-dimensional finite element analysis study demonstrates that initial fixation can be achieved with approximately 1/3 posterior glenoid bone deficiency even without screw placement in the area of bone loss. Glenoid bone loss affects baseplate fixation mainly by reducing the screw numbers for fixation. If screws can be placed in the bone loss area, the decreased baseplate back support area will not result in increased stresses or micromotion leading to baseplate failure. This study suggests that surgeons should consider applying screws to the bone loss area if the remaining bone is able to hold the screw.
Level Of Evidence: Computer Modeling Study.
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http://dx.doi.org/10.1053/j.sart.2023.08.005 | DOI Listing |
J Periodontal Res
January 2025
Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, China.
Aim: Periodontitis is a chronic inflammatory disease initiated by dysbiosis of the local microbial community. As a non-specific phosphodiesterase inhibitor, dipyridamole features anti-oxidant and anti-inflammatory properties. This study aimed to investigate the effects of dipyridamole in an experimental rat model of periodontitis.
View Article and Find Full Text PDFJ Periodontal Res
January 2025
Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
Aim: To investigate additional factors contributing to the pathophysiology of chemotherapy-induced oral mucositis and periodontitis beyond the systemic immune suppression caused by the chemotherapeutic agent 5-Fluorouracil (5-FU).
Methods: 5-Fluorouracil was topically delivered to the non-keratinized, rapidly proliferating junctional epithelium (JE) surrounding the dentition, and acts as an immunologic and functional barrier to bacterial ingression. Various techniques, including EdU incorporation, quantitative immunohistochemistry (qIHC), histology, enzymatic activity assays, and micro-computed tomographic (μCT) imaging, were employed to analyze the JE at multiple time points following topical 5-FU treatment.
Am J Sports Med
January 2025
Department of Orthopaedics, Rush University Medical Center, Rush University Medical College, Chicago, Illinois, USA.
Background: Critical analysis of studies with high level of evidence has relied on the significance set by the reported values. However, this strategy steers readers toward categorical interpretation of the data; therefore, a more comprehensive approach of data analysis is warranted. The continuous fragility index (CFI) allows for frailty interpretation of any given study's continuous outcome results.
View Article and Find Full Text PDFCell Commun Signal
January 2025
Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, 523808, China.
The prevalence of obesity and osteoporosis (OP) represents a significant public health concern on a global scale. A substantial body of evidence indicates that there is a complex relationship between obesity and OP, with a correlation between the occurrence of OP and obesity. In recent years, sirtuins have emerged as a prominent area of interest in the fields of aging and endocrine metabolism.
View Article and Find Full Text PDFBMC Oral Health
January 2025
4th Division, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, No. 22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, People's Republic of China.
Background: The stability of soft and hard tissues surrounding the implant is not only a matter of aesthetics, but also affects the long-term stability of the implant. The present study was to explore the influence of buccal mucosa width/height (W/H) ratio, emergence profile and buccal bone width on peri-implant soft and hard tissue changes in the posterior region.
Methods: Fifty-eight posterior implant restoration cases were recruited in this study.
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