The segmentally duplicated Pregnancy-specific glycoprotein () locus on chromosome 19q13 may be one of the most rapidly evolving in the human genome. It comprises ten coding genes () and one predominantly non-coding gene () that are expressed in the placenta and gut, in addition to several poorly characterized long non-coding RNAs. We report that long non-coding RNA has an oligodendrocyte-specific expression pattern and is co-expressed with genes encoding key myelin constituents. exhibits two peaks of expression during human brain development coinciding with the most active periods of oligodendrogenesis and myelination. orthologs were found in the genomes of several primates but significant expression was found only in the human, suggesting a recent evolutionary origin of its proposed role in myelination. Additionally, because co-deletion of chromosomes 1p/19q is a genomic marker of oligodendroglioma, expression of was examined in these tumors may be a promising diagnostic biomarker for glioma, with prognostic value in oligodendroglioma.
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| http://dx.doi.org/10.1016/j.ncrna.2024.06.008 | DOI Listing |
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