AI Article Synopsis
- The study investigates sex-specific factors that lead to advanced-stage diagnosis in bladder and renal cancer patients, using data from over 1,500 cases in England between 2012 and 2015.
- Female patients and those presenting with urinary tract infections or abdominal symptoms showed significantly higher odds of being diagnosed with advanced-stage bladder cancer compared to their male counterparts.
- The findings suggest that non-haematuria symptoms indicate a higher risk for advanced bladder cancer, highlighting the need for targeted interventions for women to address sex-related disparities in cancer outcomes.
Article Abstract
Background: Understanding sex-specific factors contributing to advanced-stage diagnosis can guide interventions to reduce sex inequality in patients with urological cancers.
Method: We used linked primary care and cancer registry data to examine associations between symptoms and advanced-stage in 1151 bladder cancer and 440 renal cancer patients diagnosed between January 2012 and December 2015 in England. We performed logistic regression, adjusting for sex, age, deprivation and routes to diagnosis, including interaction terms between symptoms and sex and symptoms and age.
Results: Female sex (OR vs. men 1.89 [1.28-2.79]; = 0.001) and patients presenting with urinary tract infections (OR 2.22 [1.34-3.69]) and abdominal symptoms (OR 2.19 [1.30-3.70]) were associated with increased odds of advanced-stage bladder cancer (vs. haematuria, = 0.016 for both). Women with haematuria and men with abdominal symptoms (compared with the opposite sex with the same presenting symptom) were more likely to have advanced-stage bladder cancer. Neither sex nor symptom associations were observed for renal cancer.
Conclusion: Non-haematuria symptoms are associated with higher risk of advanced-stage bladder cancer. Greater risk of advanced-stage bladder cancer in women may reflect biological differences in haematuria onset and sex differences during diagnostic process. Identifying higher risk women with haematuria may reduce sex inequalities in bladder cancer outcomes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249815 | PMC |
| http://dx.doi.org/10.1002/bco2.360 | DOI Listing |
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