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ASO Visual Abstract: Age Matters: Early-Onset Rectal Cancer Exhibits Higher Rates of Pathological Complete Response : A Retrospective Analysis of the Influence of Young Age on Treatment Success in Stage II-III Rectal Cancer.
Ann Surg Oncol
January 2025
Department of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA.
A Community Initiative to Increase Colorectal Cancer Knowledge, Awareness, and Intent to Screen in an Underserved Region.
J Dr Nurs Pract
January 2025
Texas A&M University, Corpus Christi, TX, USA.
Colorectal cancer (CRC) is a leading cause of cancer-related deaths in the United States despite the availability of effective preventive screening. This project was designed as a community awareness initiative to increase CRC awareness, knowledge, and intent to discuss and complete CRC screening. This quasi-experimental study had a QI focus and used a convenience sample in a public setting assessing CRC awareness, knowledge, and intent to discuss and complete screening after participating in an inflatable colon tour.
View Article and Find Full Text PDFGRP78: A New Promising Candidate in Colorectal Cancer Pathogenesis and Therapy.
Eur J Pharmacol
January 2025
Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Colorectal cancer (CRC) is a significant global health challenge, marked by varying incidence and mortality rates across different regions. The pathogenesis of CRC involves multiple stages, including initiation, promotion, progression, and metastasis, influenced by genetic and epigenetic factors. The chaperone protein glucose-regulated protein 78 (GRP78), crucial in regulating the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress, plays a pivotal role in CRC pathogenesis.
View Article and Find Full Text PDFNeoadjuvant chemotherapy in locally advanced colon cancer: A systematic review with proportional meta-analysis.
Eur J Surg Oncol
December 2024
Department of Medical Oncology, Catharina Hospital, Eindhoven, Netherlands.
Neoadjuvant chemotherapy is suggested in locally advanced colon cancer. Data on improved long-term oncological outcomes are lacking, which hampers the implementation in clinical practice. This systematic review provides an overview of the benefits and drawbacks of neoadjuvant chemotherapy in patients with locally advanced colon cancer.
View Article and Find Full Text PDFAssociation between lipid accumulation product and the risk of colon cancer in adults: A population-based study.
PLoS One
January 2025
Department of Gastrointestinal Surgery, Fujian Provincial Hospital, Fuzhou, China.
Background: The purpose of this study was to look into any potential connections between the occurrence of colon cancer and the condition of the body of lipid accumulation product (LAP) index.
Methods: Using data from the 2009-2018 National Health and Nutrition Examination Survey (NHANES), we performed a cross-sectional analysis with 24,592 individuals. Utilizing multivariate logistic regression modelling, the relationship between LAP levels and colon cancer risk was investigated.
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