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Reactive oxygen species of tumor microenvironment: Harnessing for immunogenic cell death. | LitMetric

Reactive oxygen species of tumor microenvironment: Harnessing for immunogenic cell death.

Biochim Biophys Acta Rev Cancer

Department of Hematology and Oncology, Heersink School of Medicine, University of Alabama, Birmingham, AL 35233, USA. Electronic address:

Published: September 2024

AI Article Synopsis

  • - The tumor microenvironment (TME) is complex and changes continuously, impacting its redox balance and supporting tumor growth by altering its cellular and molecular makeup.
  • - Despite advancements in cancer immunotherapy, its effectiveness is often restricted due to changes in the TME and low tumor immunogenicity; however, certain conventional and targeted therapies can enhance immunotherapy outcomes by inducing immunogenic cell death (ICD) through reactive oxygen species (ROS).
  • - The review highlights the importance of redox homeostasis in transforming TME from a non-responsive state to an active immune-ready state and discusses strategies to harness ROS for improving immunotherapy in less immunogenic tumors.

Article Abstract

The tumor microenvironment (TME) is a dynamic and complex system that undergoes continuous changes in its network architecture, notably affecting redox homeostasis. These alterations collectively shape a diverse ecosystem actively supporting tumor progression by influencing the cellular and molecular components of the TME. Despite the remarkable clinical advancements in cancer immunotherapy, its spectrum of clinical utility is limited by the altered TME and inadequate tumor immunogenicity. Recent studies have revealed that some conventional and targeted therapy strategies can augment the efficacy of immunotherapy even in patients with less immunogenic solid tumors. These strategies provoke immunogenic cell death (ICD) through the ROS-dependent liberation of damage-associated molecular patterns (DAMPs). These DAMPs recognize and bind with Pattern Recognition Receptors (PRRs) on immune cells, activating and maturing defense cells, ultimately leading to a robust antitumor immune response. The present review underscores the pivotal role of redox homeostasis in orchestrating the transition of TME from a cold to a hot phenotype and the ROS-ICD axis in immune response induction. Additionally, it provides up-to-date insights into strategies that leverage ROS generation to induce ICD. The comprehensive analysis aims to develop ROS-based effective cancer immunotherapies for less immunogenic tumors.

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Source
http://dx.doi.org/10.1016/j.bbcan.2024.189154DOI Listing

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