The effect of sparkling water on the systemic pharmacokinetics of paracetamol in older adults.

Int J Pharm

Drug Delivery and Disposition, KU Leuven, Herestraat 49, O&N2, box 921, 3000 Leuven, Belgium. Electronic address:

Published: September 2024

Paracetamol absorption kinetics show considerable variability in older adults, complicating the development of effective dosing regimens in the advanced-age population. In previous research, sparkling water has been shown to influence absorption-related processes. This study aimed to apply these findings to older adults and investigate the impact of sparkling water on absorption-related variability and early exposure. To this end, fourteen volunteers, with a median age of 72.5, were enrolled in a small-scale, randomised, controlled clinical trial with a cross-over design. A single immediate-release 500 mg paracetamol tablet was administered with sparkling or still water. Venous blood samples were collected regularly over 8 hours and analysed using HPLC-UV. Reduced variability of absorption-related parameters and a trend towards higher early exposure were observed in the sparkling water group, as demonstrated by a 1.6-fold increased AUC, a 2-fold reduced geometric coefficient of variation (GCV) for AUC, and a reduced median [interquartile range] T of 25.0 [20.0-30.0] min compared to 30.0 [25.0-45.0] min. Based on our findings, sparkling water as a real-life dosing condition might improve paracetamol absorption kinetics and early exposure in the advanced-age population.

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http://dx.doi.org/10.1016/j.ijpharm.2024.124482DOI Listing

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