To clarify the place of time direction of change in nature (time arrow), the present article shows why Evolution and Irreversibility are two distinct phenomena. Their distinct laws of nature are the Constructal Law and the Second Law, respectively. The demonstration is based on the simplest setting imaginable: a solid body moving in a pool of water. The view is holistic: the system selected for analysis is the body and the pool, not the body alone, and the phenomenon is the evolution of the image (configuration) of the whole. New is also the answer to the question of what flows in this evolving flow configuration. Along the way, important terms are defined: phenomenon, law, irreversibility, nature, design, freedom, theory versus empiricism, information, knowledge, selection, purpose, engine, refrigeration, and wheel. More complex natural settings for the demonstration are in the second part of the article: engines, refrigeration, heating and cooling, the wheel, and a pushed boat sliding on water.
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http://dx.doi.org/10.1016/j.plrev.2024.06.014 | DOI Listing |
Mol Ther Nucleic Acids
March 2025
Telethon Institute of Genetics and Medicine (TIGEM), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.
Inherited retinal diseases (IRDs) are clinically and genetically heterogeneous disorders characterized by progressive photoreceptor degeneration and irreversible vision loss. MicroRNAs (miRNAs), a class of endogenous non-coding RNAs with post-transcriptional regulatory properties, are known to play a major role in retinal function, both in physiological and pathological conditions. Given their ability to simultaneously modulate multiple molecular pathways, miRNAs represent promising therapeutic tools for disorders with high genetic heterogeneity, such as IRDs.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Molecular Biomimetics, Department of Chemistry, Ångström Laboratory, Uppsala University, P.O. Box 523, Uppsala SE-75120, Sweden.
[FeFe] hydrogenases make up a structurally diverse family of metalloenzymes that catalyze proton/dihydrogen interconversion. They can be classified into phylogenetically distinct groups denoted A-G, which differ in structure and reactivity. Prototypical Group A hydrogenases have high turnover rates and remarkable energy efficiency.
View Article and Find Full Text PDFInt J Food Microbiol
January 2025
School of Life Science and Technology, Shandong Second Medical University, Weifang, Shandong, China. Electronic address:
Escherichia coli O157:H7 has caused many foodborne disease outbreaks and resulted in unimaginable economic losses. With the evolution of food consumption, people prefer natural preservatives. In this study, the natural agent harmane exhibited potential activity against E.
View Article and Find Full Text PDFEntropy (Basel)
December 2024
Independent Researcher, Leesburg, VA 20176, USA.
Vopson and Lepadatu recently proposed the Second Law of Infodynamics. The law states that while the total entropy increases, information entropy declines over time. They state that the law has applications over a wide range of disciplines, but they leave many key questions unanswered.
View Article and Find Full Text PDFAdv Mater
January 2025
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
Layered transition metal oxides (LTMOs) are attractive cathode candidates for rechargeable secondary batteries because of their high theoretical capacity. Unfortunately, LTMOs suffer from severe capacity attenuation, voltage decay, and sluggish kinetics, resulting from irreversible lattice oxygen evolution and unstable cathode-electrolyte interface. Besides, LTMOs accumulate surface residual alkali species, like hydroxides and carbonates, during synthesis, limiting their practical application.
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