Background: Contribution of dominance effects to cancer heritability is unknown. We leveraged existing genome-wide association data for seven cancers to estimate the contribution of dominance effects to the heritability of individual cancer types.
Methods: We estimated the proportion of phenotypic variation caused by dominance genetic effects using genome-wide association data for seven cancers (breast, colorectal, lung, melanoma, nonmelanoma skin, ovarian, and prostate) in a total of 166,772 cases and 284,824 controls.
Results: We observed no evidence of a meaningful contribution of dominance effects to cancer heritability. By contrast, additive effects ranged between 0.11 and 0.34.
Conclusions: In line with studies of other human traits, the dominance effects of common genetic variants play a minimal role in cancer etiology.
Impact: These results support the assumption of an additive inheritance model when conducting cancer association studies with common genetic variants.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446654 | PMC |
| http://dx.doi.org/10.1158/1055-9965.EPI-24-0496 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Effect of Cataract Surgery on Stereoacuity, Balance, and Falls in Patients With Senile Cataract.
Eye Contact Lens
January 2025
Department of Ophthalmology (O.O.), Niğde Ömer Halisdemir University, Niğde, Turkey; Department of Ophthalmology (O.D.), Mersin University, Mersin, Turkey; Department of Ophthalmology (P.E.), Tarsus State Hospital, Mersin, Turkey; and Department of Ophthalmology (E.S.G.), Mersin State Hospital, Mersin, Turkey.
Objectives: To investigate the effect of cataract surgery on visual acuity, stereoacuity, balance, and falls in patients with senile cataract.
Methods: Prospective, cross-sectional study. The patients were divided into group 1 if the first surgery was performed on the dominant eye and group 2 on the nondominant eye.
Exploring volatility transmission in Capesize freight contracts: Insights from energy and commodity markets.
PLoS One
January 2025
School of Economics & Management, Shanghai Maritime University, Shanghai, China.
Analyzing the interactions between spot and time charter freight is crucial for the maritime industry. While numerous studies have explored the relationship between average freight indices and spillover effects, a gap remains in understanding the deeper connections between inter-regional shipping routes and chartering contracts. This research investigates the role of Capesize freight dynamics in shaping the regional dry bulk freight market, with a focus on the influence of energy and commodity price fluctuations.
View Article and Find Full Text PDFFunctional traits mediate the effect of land use on drivers of community stability within and across trophic levels.
Sci Adv
January 2025
Forest Entomology, Swiss Federal Research Institute WSL, Birmensdorf, Switzerland.
Understanding how land use affects temporal stability is crucial to preserve biodiversity and ecosystem functions. Yet, the mechanistic links between land-use intensity and stability-driving mechanisms remain unclear, with functional traits likely playing a key role. Using 13 years of data from 300 sites in Germany, we tested whether and how trait-based community features mediate the effect of land-use intensity on acknowledged stability drivers (compensatory dynamics, portfolio effect, and dominant species variability), within and across plant and arthropod communities.
View Article and Find Full Text PDFPolycyclic aromatic hydrocarbons from environmental tobacco smoke and wood stoves dominate in settled house dust from Northwestern Ontario First Nations communities.
Int J Circumpolar Health
December 2025
Department of Chemistry, Carleton University, Ottawa, ON, Canada.
Rates of respiratory tract infections for children living in remote First Nations communities in the Sioux Lookout Zone in Northwestern Ontario are elevated and associated with poor indoor environmental quality including high exposures to endotoxin and serious dampness and mould damage. The studies also revealed a high prevalence of cigarette smoking and most houses have wood stoves, of variable quality. Depending on structure, polycyclic aromatic hydrocarbons (PAH) are carcinogens, immunotoxins and/or inflammatory mediators that are byproducts of the incomplete combustion of organic materials.
View Article and Find Full Text PDFPersistent Effects of Landscape Context on Recruitment Dynamics During Secondary Succession of Tropical Forests.
Glob Chang Biol
January 2025
GEMA Center for Genomics, Ecology & Environment, Universidad Mayor, Santiago, Chile.
Large-scale reforestation is promoted as an important strategy to mitigate climate change and biodiversity loss. A persistent challenge for efforts to restore ecosystems at scale is how to accelerate ecological processes, particularly natural regeneration. Yet, despite being recognized as an important barrier to the recovery of diverse plant communities in tropical agricultural landscapes, the impacts of dispersal limitation on natural regeneration in secondary forests-and especially how this changes as these forests grow older-are still poorly studied.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!