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http://dx.doi.org/10.18632/oncotarget.28610 | DOI Listing |
PLoS One
January 2025
Headquarters, Secufind Co., Seoul, Republic of Korea.
In the dynamic field of organizational behavior, comprehending the determinants of employee engagement, burnout, and job satisfaction is pivotal. This research investigates the influence of various workplace factors, such as recognition, fairness, leadership, and workload, on these key employee outcomes. Utilizing Partial Least Squares Structural Equation Modeling (PLS-SEM) for analysis, the study examines data from 25,285 employees.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
Background: Inflammation is becoming increasingly recognised as a core feature of dementia and neurodegenerative processes. High-sensitivity C-reactive protein (hs-CRP) and homocysteine are blood-based markers of non-specific inflammation used in clinical settings. This study aimed to 1) investigate the associations of hs-CRP and homocysteine on neuropsychological performance (i.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.
Background: There is evidence indicating that disruptions in lipid metabolism are implicated in the pathophysiology of Alzheimer's disease (AD), with systemic repercussions that can be identified in peripheral blood. Recent studies conducted by our group have identified abnormalities in lipid metabolism among patients with mild cognitive impairment (MCI) and dementia (probable AD), through the investigation of a specific panel of lipid metabolites in plasma. Although much remains to be elucidated about the complex interaction between disturbances in lipid metabolites and the pathogenesis of AD, this promising research area offers exciting opportunities for the development of new strategies for disease diagnosis, treatment, and prevention.
View Article and Find Full Text PDFBackground: The cortex responsible for language processing is among the earliest areas affected by Alzheimer's Disease (AD), manifesting speech and language abnormalities even before formal diagnosis. Language decline in AD is clinically significant, often parallel to a loss in basic daily living abilities. Research endeavors to detect AD early through automated speech analysis, emphasizing the need to comprehend factors influencing language disruption.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Background: The blood-brain barrier (BBB) is considered the crucial part of neuroprotection from various neurological insults including infection, inflammation, and neurodegeneration including Alzheimer's disease (AD). The cerebral small vessel disease (CSVD) pathologies especially cerebral microbleeds (CMBs) and gadolinium enhancement might reflect the disruption of BBB. The correlation between BBB permeability measured by cerebrospinal fluid (CSF)/plasma albumin quotient (Qalb) and CSVD biomarkers is poorly understood.
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