We report a woman who developed renal failure due to focal glomerulosclerosis (FGS). This disease recurred immediately in a kidney transplant from her brother resulting in removal of that graft. She subsequently received a cadaver kidney transplant, and FGS has not recurred after 24 months. This is the first report of nonrecurrence in a second kidney graft, when the first was lost due to recurrent FGS. Whether timing or tissue typing of the second graft in relationship to the first is important is not known. Recurrence of FGS in a first kidney graft should not, however, preclude future transplantation.
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