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Missing pieces in the puzzle of ecology of microbial arsenate reduction.
J Hazard Mater
December 2024
Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Institute of Eco-environmental and Soil Sciences, National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Academy of Sciences, Guangzhou 510650, China.
Arsenic pollution and its associated health risks have raised widespread concern. Under anaerobic conditions, arsenic mobility and toxicity increase when arsenate [As(V)] is reduced to arsenite [As(III)] by microbes through the cytoplasmic and dissimilatory pathways. However, the relative importance of these two pathways in the environment remains unclear, restricting our ability to effectively predict and regulate the environmental behavior of arsenic.
View Article and Find Full Text PDFHuman brain aging is associated with dysregulation of cell type epigenetic identity.
Geroscience
December 2024
Department of Ecology, Evolution, and Marine Biology, Department of Molecular, Cellular, and Cell Biology, Neuroscience Research Institute, University of California, Santa Barbara, CA, 93106, USA.
Significant links between aging and DNA methylation are emerging from recent studies. On the one hand, DNA methylation undergoes changes with age, a process termed as epigenetic drift. On the other hand, DNA methylation serves as a readily accessible and accurate biomarker for aging.
View Article and Find Full Text PDFMechanism of the Mitsunobu Reaction: An Ongoing Mystery.
Synthesis (Stuttg)
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Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA.
The Mitsunobu reaction is one the most widely known reactions in the organic chemistry canon. Despite its fame, some aspects of the mechanism remain poorly understood, 55 years after its initial discovery. This short review collates the findings of several publications focused on the mechanism of the Mitsunobu reaction, highlighting both the current state of knowledge and the remaining missing pieces.
View Article and Find Full Text PDFThe missing pieces: an investigation into the parallels between Charles Bonnet, phantom limb and tinnitus syndromes.
Ther Adv Ophthalmol
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Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Charles Bonnet syndrome (CBS) is a condition characterised by visual hallucinations of varying complexity on a background of vision loss. CBS research has gained popularity only in recent decades, despite evidence dating back to 1760. Knowledge of CBS among both the patient and professional populations unfortunately remains poor, and little is known of its underlying pathophysiology.
View Article and Find Full Text PDFOptimizing infant neuroimaging methods to understand the neurodevelopmental impacts of early nutrition and feeding.
Dev Cogn Neurosci
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Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA; Department of Human Development and Family Science, Virginia Tech, Blacksburg, VA, USA. Electronic address:
There is strong evidence proper nutrition is imperative for healthy infant neurodevelopment, providing the neural foundations for later cognition and behavior. Over the first years of life infants are supported by unique sources of nutrition (e.g.
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