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Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trials.
EClinicalMedicine
January 2025
University of Paris Cité, Inserm UMR-S 942, Cardiovascular Markers in Stress Conditions (MASCOT), Paris, France.
Background: Cardiogenic shock (CS) is a heterogeneous clinical syndrome, making it challenging to predict patient trajectory and response to treatment. This study aims to identify biological/molecular CS subphenotypes, evaluate their association with outcome, and explore their impact on heterogeneity of treatment effect (ShockCO-OP, NCT06376318).
Methods: We used unsupervised clustering to integrate plasma biomarker data from two prospective cohorts of CS patients: CardShock (N = 205 [2010-2012, NCT01374867]) and the French and European Outcome reGistry in Intensive Care Units (FROG-ICU) (N = 228 [2011-2013, NCT01367093]) to determine the optimal number of classes.
Enhancing sidewalk accessibility assessment for wheelchair users: An adaptive weighting fuzzy-based approach.
Heliyon
January 2025
Center for Research in Geospatial Data and Intelligence, Department of Geomatics Sciences, Université Laval, 1055, Avenue Du Séminaire, Québec, QC, Canada.
To reach a destination within the community, it is crucial that wheelchair users possess the ability to plan, execute, and acquire knowledge of routes in a safe and efficient manner. While numerous methods have been introduced for assessing the accessibility of sidewalks, existing studies often overlook the variations in the perception of the accessibility of long segments based on each wheelchair user's capabilities. Extended distances may lead to increased fatigue, impacting the ability of individuals with mobility disabilities to navigate sidewalks comfortably and independently.
View Article and Find Full Text PDFUnilateral chylothorax in a renal transplant recipient: A case report.
Urol Case Rep
January 2025
Department of Urology, Faculty of Medicine, University of Indonesia, Central Jakarta, Special Capital Region of Jakarta, Indonesia.
Chylothorax is accumulated lymphatic fluid in the pleural space. It rarely happens in end-stage renal illness patients, but possible causes are hospital-related. This case describes a 40-year-old man experiencing unilateral chylothorax after a kidney transplant.
View Article and Find Full Text PDFDegradation of naphthalene in aqueous solution using a microbial symbiotic system founded by degrading and ureolytic bacteria.
Environ Res
January 2025
, UniSA STEM, ScaRCE, University of South Australia, SA 5000, Australia. Electronic address:
Although single bacteria have been applied to the Polycyclic Aromatic Hydrocarbons (PAHs) remediation, its efficacy is severely restricted by long degradation periods and low efficacy. A microbial symbiotic system founded by two or more bacterial strains may be an alternative to traditional remediation approaches. Its construction is, however, hampered by antagonistic interactions and remains challenging.
View Article and Find Full Text PDFReversible light-responsive protein hydrogel for on-demand cell encapsulation and release.
Acta Biomater
January 2025
Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX, 78712, USA. Electronic address:
The design of biomaterials that can reconfigure on-demand in response to external stimuli is an emerging area in materials research. However, achieving reversible assembly of protein-based biomaterials by light input remains a major challenge. Here, we present the engineering of a new protein material that is capable of switching between liquid and solid state reversibly, controlled by lights of different wavelengths.
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