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A deep learning approach to real-time Markov modeling of ion channel gating.
Commun Chem
November 2024
Institut für Physiologie und Pathophysiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
The patch-clamp technique allows us to eavesdrop the gating behavior of individual ion channels with unprecedented temporal resolution. The signals arise from conformational changes of the channel protein as it makes rapid transitions between conducting and non-conducting states. However, unambiguous analysis of single-channel datasets is challenging given the inadvertently low signal-to-noise ratio as well as signal distortions caused by low-pass filtering.
View Article and Find Full Text PDFUltra-Reliable and Low-Latency Wireless Hierarchical Federated Learning: Performance Analysis.
Entropy (Basel)
September 2024
School of Information Science and Technology, Southwest JiaoTong University, Chengdu 611756, China.
Article Synopsis
- Wireless Hierarchical Federated Learning (WHFL) improves model training efficiency by using a cloud-edge-client architecture, but is vulnerable to eavesdropping during wireless communications.
- The paper addresses this issue by proposing a secure finite block-length (FBL) approach for protecting data in multi-antenna systems within ultra-reliable low-latency communication (URLLC) frameworks.
- Simulation results demonstrate that the FBL method achieves near-perfect secrecy while maintaining strong learning performance, even when facing challenges like imperfect channel state information (CSI) of eavesdroppers.
Identification of new SdiA regulon members of , , and serovars Typhimurium and Typhi.
Microbiol Spectr
October 2024
Department of Microbiology, The Ohio State University, Columbus, Ohio, USA.
Article Synopsis
- - Bacteria like Typhimurium and Typhi utilize a method called quorum sensing to detect population density through small molecules, specifically acyl homoserine lactones (AHLs), despite lacking the ability to produce these signals themselves; they can sense them using a receptor called SdiA, engaging in behavior known as eavesdropping.
- - RNA-seq analysis reveals that even though Typhimurium and Typhi have different pathogenic strategies, their regulatory networks (regulons) related to AHL detection are largely conserved, with some overlap in gene functions observed when testing related genes between the two serovars.
- - Many genes regulated by AHLs in these bacteria are not well understood, and the overall significance
Alarm calls of sagebrush converge when herbivory is high.
Proc Biol Sci
September 2024
Department of Environmental and Biological Sciences, University of Eastern Finland, Yliopistonranta 8 , Kuopio 70211, Finland.
Herbivory is a major threat to virtually all plants, so adaptations to avoid herbivory will generally be selected. One potential adaptation is the ability to 'listen in' on the volatile cues emitted by plants that are experiencing herbivory and to then respond by ramping up defences. The nature of these volatile cues is poorly understood.
View Article and Find Full Text PDFThe past, present and future of polymicrobial infection research: Modelling, eavesdropping, terraforming and other stories.
Adv Microb Physiol
July 2024
Department of Biochemistry, Tennis Court Road, Cambridge, United Kingdom. Electronic address:
Over the last two centuries, great advances have been made in microbiology as a discipline. Much of this progress has come about as a consequence of studying the growth and physiology of individual microbial species in well-defined laboratory media; so-called "axenic growth". However, in the real world, microbes rarely live in such "splendid isolation" (to paraphrase Foster) and more often-than-not, share the niche with a plethora of co-habitants.
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