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Metabolic and Bariatric Operation and the Path to Kidney Transplantation.
J Am Coll Surg
January 2025
Department of Surgery, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Background: Obesity is a significant barrier to kidney transplantation for patients with end-stage renal disease (ESRD). We aimed to evaluate the long-term impact of metabolic and bariatric surgery (MBS) on kidney transplantation access and outcomes in individuals with obesity and ESRD patients.
Study Design: A retrospective cohort study using data from 64 US healthcare organizations included 132,989 individuals with obesity (BMI ≥30kg/m²) and ESRD requiring dialysis, of whom 6,263 (4.
Membrane drug transporters in cancer: From chemoresistance mechanism to therapeutic strategies.
Biochim Biophys Acta Rev Cancer
January 2025
Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau, China; Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau, China. Electronic address:
Chemoresistance is a multifactorial phenomenon and the primary cause to the ineffectiveness of oncotherapy and cancer recurrence. Membrane drug transporters are crucial for drug delivery and disposition in cancer cells. Changes in the expression and functionality of these transporters lead to decreased intracellular accumulation and reduced toxicity of antineoplastic drugs.
View Article and Find Full Text PDFOptimization and Evaluation of -Based Magistral Formulations: A Path to Personalized Therapy.
Pharmaceuticals (Basel)
January 2025
Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland.
Introduction: The official implementation of pharmaceutical-grade cannabis raw materials for medicinal use has permitted doctors to prescribe and pharmacists to prepare cannabis-based formulations. The objective of the pharmaceutical development and manufacturing process optimization work was to propose a suppository formulation containing doses of 25 mg and 50 mg of tetra-hydrocannabinol (∆-9-THC) as an alternative to existing inhalable or orally administered formulations. The formulation could be used for rectal or vaginal administration, thereby providing dosage control in the treatment of endometriosis and other conditions involving pain.
View Article and Find Full Text PDFData Fusion Applied to the Leader-Based Bat Algorithm to Improve the Localization of Mobile Robots.
Sensors (Basel)
January 2025
Department of Electrical Engineering, Universidade Federal do Espírito Santo, Vitória 29075-910, ES, Brazil.
The increasing demand for autonomous mobile robots in complex environments calls for efficient path-planning algorithms. Bio-inspired algorithms effectively address intricate optimization challenges, but their computational cost increases with the number of particles, which is great when implementing algorithms of high accuracy. To address such topics, this paper explores the application of the leader-based bat algorithm (LBBA), an enhancement of the traditional bat algorithm (BA).
View Article and Find Full Text PDFStandardization for Data Generation and Collection in the Dairy Industry: Addressing Challenges and Charting a Path Forward.
Animals (Basel)
January 2025
Zinpro Corporation, Eden-Prairie, MN 55344, USA.
Standards for data generation and collection are important for integration and for achieving data-driven actionable insights in dairy farming. Data integration and analysis are critical for advancing the dairy industry, enabling better decision-making, and improving operational efficiencies. This commentary paper discusses the challenges of and proposes pathways for standardizing data generation and collection based on insights from a multidisciplinary group of stakeholders.
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