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Systemic and Cardiac Microvascular Dysfunction in Hypertension.
Int J Mol Sci
December 2024
Dipartimento di Biotecnologie e Scienze della Vita, ASST Sette Laghi, Università degli Studi dell'Insubria, 21100 Varese, Italy.
Hypertension exerts a profound impact on the microcirculation, causing both structural and functional alterations that contribute to systemic and organ-specific vascular damage. The microcirculation, comprising arterioles, capillaries, and venules with diameters smaller than 20 μm, plays a fundamental role in oxygen delivery, nutrient exchange, and maintaining tissue homeostasis. In the context of hypertension, microvascular remodeling and rarefaction result in reduced vessel density and elasticity, increasing vascular resistance and driving end-organ damage.
View Article and Find Full Text PDFMonitoring Progression in Hypertensive Patients with Dyslipidemia Using Optical Coherence Tomography Angiography: Can A.I. Be Improved?
J Clin Med
December 2024
Physio-Pathology and Immunology Department, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
: With the development of artificial intelligence (A.I.), the optical coherence tomography angiography (OCTA) analysis of progression in hypertensive retinopathy could be improved.
View Article and Find Full Text PDFReceptor-Interacting Protein Kinase-3 Expression Impacts Ocular Vascular Development and Pathological Neovascularization.
Cells
December 2024
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Functional cell death pathways are essential for normal ocular vascular development and tissue homeostasis. As our understanding of necrosis-based cell death pathways has expanded, the inclusion of regulated forms, including necroptosis, ferroptosis, and oxytosis, has occurred. Although the existence of these pathways is well described, our understanding of their role during vascular development and pathological neovascularization is very limited.
View Article and Find Full Text PDFVDMNet: A Deep Learning Framework with Vessel Dynamic Convolution and Multi-Scale Fusion for Retinal Vessel Segmentation.
Bioengineering (Basel)
November 2024
Department of Neurosurgery, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen 518052, China.
Retinal vessel segmentation is crucial for diagnosing and monitoring ophthalmic and systemic diseases. Optical Coherence Tomography Angiography (OCTA) enables detailed imaging of the retinal microvasculature, but existing methods for OCTA segmentation face significant limitations, such as susceptibility to noise, difficulty in handling class imbalance, and challenges in accurately segmenting complex vascular morphologies. In this study, we propose VDMNet, a novel segmentation network designed to overcome these challenges by integrating several advanced components.
View Article and Find Full Text PDFSlab-Specific Projection-Resolved Optical Coherence Tomography Angiography for Enhancing En Face Polyp Detection in Polypoidal Choroidal Vasculopathy.
Invest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Purpose: A projection-resolved optical coherence tomography angiography (PR-OCTA) algorithm with slab-specific strategy was applied in polypoidal choroidal vasculopathy (PCV) to differentiate between polyp and branching vascular network (BVN) and improve polyp detection by en face OCTA.
Methods: Twenty-nine participants diagnosed with PCV by indocyanine green angiography (ICGA) and 30 participants diagnosed with typical neovascular age-related macular degeneration (nAMD) were enrolled. Polyps were classified into three categories after using the slab-specific PR algorithm.
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