AI Article Synopsis
- COVID-19, caused by SARS-CoV-2, can lead to gastrointestinal issues like severe diarrhea, which may persist even after recovery from the virus.
- A 50-year-old man with COVID-19 pneumonia developed refractory diarrhea that reached alarming volumes, leading to further medical intervention and treatment for a suspected enterocolitis linked to the virus.
- Administering methylprednisolone significantly improved the patient's condition, suggesting that corticosteroids may be beneficial for post-COVID-19 patients experiencing severe diarrhea due to abnormal immune responses.
Article Abstract
Introduction: Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is frequently associated with various gastrointestinal symptoms, including abdominal pain, vomiting, and diarrhea. Moreover, several cases of refractory diarrhea have been reported after COVID-19 recovery. Herein, we present a case of severe refractory diarrhea associated with COVID-19.
Case Presentation: A 50-year-old man with no comorbidities was admitted to our hospital with SARS-CoV-2 pneumonia. His respiratory status deteriorated, and ventilatory management, including extracorporeal membrane oxygenation, was needed. The patient's respiratory condition improved, resulting in a transfer to another hospital for rehabilitation. However, the patient developed diarrhea that worsened to 6,000-7,000 mL/day, and he was transferred to our hospital. We diagnosed the patient with enterocolitis caused by cytomegalovirus infection and treated him with ganciclovir on day 5 after transfer to our hospital. The diarrhea did not improve. We suspected enterocolitis associated with COVID-19 and administered a methylprednisolone pulse (intravenous injection, 1,000 mg/day for 3 days) on day 10 after transfer, resulting in a marked improvement in his symptoms. The prednisolone dose was tapered, and no recurrence of diarrhea was observed thereafter.
Conclusion: The prevalence of COVID-19-associated enterocolitis is low, and the pathogenesis of the disease remains unclear. Prednisolone administration should be considered in cases of post-COVID-19 symptoms of severe diarrhea due to a possible abnormal immune response related to COVID-19.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250576 | PMC |
| http://dx.doi.org/10.1159/000539413 | DOI Listing |
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