This study investigates the impact of C and C fullerenes on quinazolinone, specifically in quinazolinone-fulleropyrrolidine nanohybrids. The nanohybrids and exhibit distinct spectral shifts and have significant photobiological antineoplastic properties. enhances apoptosis, while reduces Cyclin A levels and counteracts oncogenic effects by promoting cell differentiation. demonstrates heightened cytotoxicity by overcoming chemotherapy resistance by modulating and levels. This innovative approach, distinguishing between C and C, represents a novel contribution to the existing scientific literature.
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http://dx.doi.org/10.1021/acsmedchemlett.4c00187 | DOI Listing |
Adv Mater
December 2024
Institute of Molecular Plus, Department of Chemistry and Haihe Laboratory of Sustainable Chemical Transformations, Key Laboratory of Organic Integrated Circuits, Ministry of Education, Tianjin University, Tianjin, 300072, China.
Organic photodiodes (OPDs) that utilize wavelength-selective absorbing molecules offer a direct approach to capturing specific wavelengths of light in multispectral sensors/imaging systems without filters. However, they exhibit broad response bandwidths, low external quantum efficiency (EQE), and often require compromises in two-component photoactive materials. Herein, the first utility of boron-nitrogen (BN) single-component photoabsorbers, leveraging a multi-resonance effect are introduced to attain OPDs with both record-high EQE of 33.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
State Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 350002, Fuzhou, Fujian, P. R. China.
Antiferroelectric (AFE) has emerged as a promising branch of electroactive materials, due to intriguing physical attributes stemming from the electric field-induced antipolar-to-polar phase transformation. However, the requirement of extremely high electric field strength to switch adjacent sublattice polarization poses great challenges for exploiting new molecular AFE system. Although photoirradiation is striking as a noncontact and nondestructive manipulation tool to optimize physical properties, optical control of antiferroelectricity still remains unexplored.
View Article and Find Full Text PDFACS Med Chem Lett
July 2024
Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata-700064, West Bengal, India.
This study investigates the impact of C and C fullerenes on quinazolinone, specifically in quinazolinone-fulleropyrrolidine nanohybrids. The nanohybrids and exhibit distinct spectral shifts and have significant photobiological antineoplastic properties. enhances apoptosis, while reduces Cyclin A levels and counteracts oncogenic effects by promoting cell differentiation.
View Article and Find Full Text PDFBiomater Adv
July 2024
Department of Chemical and Petroleum Engineering, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada. Electronic address:
Essential organs, such as the heart and liver, contain a unique porous network that allows oxygen and nutrients to be exchanged, with distinct random to ordered regions displaying varying degrees of strength. A novel technique, referred to here as flow-induced lithography, was developed. This technique generates tunable anisotropic three-dimensional (3D) structures.
View Article and Find Full Text PDFStruct Dyn
March 2024
National Institutes of Health, NIDDK, LCP, Bethesda, Maryland 20892, USA.
Photoactive yellow protein (PYP) is a signaling protein whose internal p-coumaric acid chromophore undergoes reversible, light-induced -to- isomerization, which triggers a sequence of structural changes that ultimately lead to a signaling state. Since its discovery nearly 40 years ago, PYP has attracted much interest and has become one of the most extensively studied proteins found in nature. The method of time-resolved crystallography, pioneered by Keith Moffat, has successfully characterized intermediates in the PYP photocycle at near atomic resolution over 12 decades of time down to the sub-picosecond time scale, allowing one to stitch together a movie and literally watch a protein as it functions.
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