Herein, we describe the total synthesis of the depsipeptide vioprolide B and of an analogue, in which the ()-dehydrobutyrine amino acid was replaced by glycine. The compounds were studied in biological assays which revealed cytotoxicity solely for vioprolide B presumably by covalent binding to cysteine residues of elongation factor eEF1A1 and of chromatin assembly factor CHAF1A.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1039/d4cc02946a | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!