Herein, we describe the total synthesis of the depsipeptide vioprolide B and of an analogue, in which the ()-dehydrobutyrine amino acid was replaced by glycine. The compounds were studied in biological assays which revealed cytotoxicity solely for vioprolide B presumably by covalent binding to cysteine residues of elongation factor eEF1A1 and of chromatin assembly factor CHAF1A.

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http://dx.doi.org/10.1039/d4cc02946aDOI Listing

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