AI Article Synopsis

  • Chronic Otitis Media (COM) is a long-term ear infection caused by bacteria due to issues with the eardrum and often involves antibiotic resistance.
  • Research evaluated the natural drug 1,8-Cineol as an off-label treatment for COM, showing it reduced harmful bacteria and led to better health outcomes in some patients.
  • This study highlights the anti-inflammatory benefits of 1,8-Cineol, suggesting potential improvements in treatment options for COM with further investigation into how it works.

Article Abstract

Chronic Otitis Media (COM) is defined as long term inflammation and colonization with pathogenic bacteria due to a defect or retraction of the tympanic membrane. Surgical interventions are often augmented by antibiotic resistance development and therefore, off-label treatment using the natural drug 1,8-Cineol was carried out. All COM patients underwent antibiotic therapy and middle ear surgery and developed antibiotic resistances. Microbiological investigations from the auditory canal and stool samples were performed in correlation with the clinical course. Therapy of COM patients with 1,8-Cineol revealed a clear reduction of inflammatory microbes P. aeruginosa and Proteus mirabilis in ear samples as well as intestinal Prevotella copri, which was associated with an improved clinical outcome in certain individuals. The present off-label study revealed manifold anti-inflammatory effects of the natural monoterpene 1,8-Cineol in Otitis media patients. A better understanding of the underlying mechanisms will improve the current treatment options and possible forms of application of this natural drug.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11252366PMC
http://dx.doi.org/10.1038/s41598-024-67498-5DOI Listing

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