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Elemene Injection Suppresses Pancreatic Cancer Progress through Regulating Cell Adhesion: A Research Based upon Network Pharmacology and Verification Test.
Curr Med Chem
January 2025
Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Background: This study investigates the potential effects of elemene injection on pancreatic cancer using network pharmacology and experimental validation.
Methods: GEO database were used to acquire genes which are differentially expressed between pancreatic cancer tissue and normal tissue. The vigorous energetic ingredients were identified in research and the object genes were obtained from BATMAN-TCM.
Fabrication of PTFE + TiO/Ag coatings on 316L/polydopamine with advanced mechanical, bio-corrosion, and antibacterial properties for stainless steel Catheters.
J Biomater Sci Polym Ed
September 2024
Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran.
This study explores the corrosion resistance and antibacterial properties of a PTFE + TiO/Ag coating applied to 316 L stainless steel. To enhance adhesion, a polydopamine interlayer was chemically deposited onto the steel surface. The PTFE + TiO coating was subsequently applied through immersion, followed by the deposition of silver nanoparticles using a chemical method.
View Article and Find Full Text PDFAn injectable and antifouling hydrogel prevents the development of abdominal adhesions by inhibiting the CCL2/CCR2 interaction.
Biomaterials
December 2024
School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address:
Abdominal adhesion, a serious complication of abdominal surgery, often resists mitigation by current drug administration and physical barriers. To address this issue, we developed an injectable, antifouling hydrogel through the free-radical polymerization of methacrylate chondroitin sulfate (CS-GMA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) monomers, dubbed the CGM hydrogel. We systematically analyzed its physicochemical properties, including rheological strength, biocompatibility, and antifouling capabilities.
View Article and Find Full Text PDFBiocompatible Nanocomposites for Postoperative Adhesion: A State-of-the-Art Review.
Nanomaterials (Basel)
December 2023
Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
To reduce and prevent postsurgical adhesions, a variety of scientific approaches have been suggested and applied. This includes the use of advanced therapies like tissue-engineered (TE) biomaterials and scaffolds. Currently, biocompatible antiadhesive constructs play a pivotal role in managing postoperative adhesions and several biopolymer-based products, namely hyaluronic acid (HA) and polyethylene glycol (PEG), are available on the market in different forms (e.
View Article and Find Full Text PDFApplication of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review.
Gels
January 2023
School of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, China.
Postoperative adhesion is a common post-surgery complication formed between the surface of the body cavity, ranging from a layer of connective tissue to a fibrous bridge containing blood vessels and nerve tissue. Despite achieving a lot of progress, the mechanisms of adhesion formation still need to be further studied. In addition, few current treatments are consistently effective in the prevention of postoperative adhesion.
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