Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1200/PO.24.00344 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A mating mechanism to generate diversity for the Darwinian selection of DNA-encoded synthetic molecules.
Nat Chem
February 2022
Department of Organic Chemistry, NCCR Chemical Biology, Faculty of Science, University of Geneva, Geneva, Switzerland.
DNA-encoded library technologies enable the screening of synthetic molecules but have thus far not tapped into the power of Darwinian selection with iterative cycles of selection, amplification and diversification. Here we report a simple strategy to rapidly assemble libraries of conformationally constrained peptides that are paired in a combinatorial fashion (suprabodies). We demonstrate that the pairing can be shuffled after each amplification cycle in a process similar to DNA shuffling or mating to regenerate diversity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!