AI Article Synopsis
- The study examined the reactivity of cold thyroid nodule cells in comparison to normal thyroid cells and other thyroid conditions, focusing on the effects of various hormones and substances in culture.
- The experiment took place over 9-10 days using monolayer and organocultures, assessing protein synthesis, cytochemical, and cytoenzymatic activities.
- Results indicated that TSH and estradiol caused significant changes in CN cell nuclei, suggesting potential risks for malignancy.
Article Abstract
The authors have studied the reactivity of cold thyroid nodule cells (CN) by comparison with the reactivity of normal thyroid cells (Ty), hot nodules cells (N), Graves' disease cells (G) and cells from the area proximal to cold nodules (TyC), under the influence of increased amounts of T3, TSH, STH, insulin, estradiol and KI present in the culture medium. The experiment lasted for 9-10 days. The study was carried out on monolayer cultures of cells obtained by tripsinization and on organocultures. Proteic synthesis, cytochemical and cytoenzymatic activities in the culture under the influence of the above substances were examined comparatively. After interruption of the treatment, the monolayer cultures were stained with Giemsa and examined by light microscopy. Proteic synthesis and release of Tg, T3 and T4 into the culture medium, were also examined. The organocultures were used in evaluating 125I uptake from the medium under the influence of the treatment. The results showed variation in relation to the tissue and hormone dose applied. It was especially found that TSH and estradiol cause enlargement of CN cell nuclei and an increased number of mitoses and polyploidia which might be premises for possible malignization.
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