A new chemodosimeter SWJT-31 with an aggregation-induced emission (AIE) effect was designed and constructed. Upon increasing the water fraction in the solution, it exhibited typical AIE, which showed bright red fluorescence at 610 nm. SWJT-31 could sensitively and specifically recognize hydrazine by the TICT effect with an LOD of 33.8 nM, which was much lower than the standard of the USEPA. A portable test strip prepared using SWJT-31 was also developed for the visual detection of hydrazine. Eventually, it was successfully used for the detection of hydrazine in water samples and HeLa cells.
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http://dx.doi.org/10.1039/d4ob01009d | DOI Listing |
BMC Med Res Methodol
December 2024
Center of Clinical Pharmacology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background: Liver injury from drug-drug interactions (DDIs), notably with anti-tuberculosis drugs such as isoniazid, poses a significant safety concern. Electronic medical records contain comprehensive clinical information and have gained increasing attention as a potential resource for DDI detection. However, a substantial portion of adverse drug reaction (ADR) information is hidden in unstructured narrative text, which has yet to be efficiently harnessed, thereby introducing bias into the research.
View Article and Find Full Text PDFPolyhedron gold nanocrystals enclosed by high-index facets (HIF-Au NCs) are in high demand but are very difficult to prepare. To address this issue, we presented a simple, seedless method for synthesizing uniform HIF-Au NCs in an aqueous solution, which remarkably reduced the synthesis difficulty. Interestingly, the protonated NH which served as both the reducing and capping agent played a crucial role in modulating the kinetic growth of the HIF-Au NCs.
View Article and Find Full Text PDFAnal Chem
December 2024
Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China.
Hydroxyl radical (·OH), taken as the most active and aggressive reactive oxygen species (ROS), plays an important role in cell redox regulation and ferroptosis processes. It is a great challenge to develop methods for highly selective and sensitive detection and imaging of ·OH. A new near-infrared (NIR) fluorescence probe was designed and synthesized by introducing 3-methylpyrazolone as the specific recognition moiety to the hemicyanine backbone of the NIR fluorophore , which formed with the hydrazine group.
View Article and Find Full Text PDFJ Hazard Mater
December 2024
School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China. Electronic address:
Hydrazine, a compound recognized for its carcinogenic and genotoxic properties, presents a significant threat to human health via environmental exposure and drug metabolism. The detection of hydrazine is essential for safeguarding human health. However, a tool capable of accurately detecting hydrazine across diverse sample types, such as soil, water sources, and plant specimens contaminated by hydrazine leakage, as well as cells and live mice containing endogenously generated hydrazine from drug metabolism, is still lacking.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
March 2025
Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Guangxi Normal University), Ministry of Education, Guilin 541004, China; Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin 541004, China; Guangxi Key Laboratory of Environmental Processes and Remediation in Ecologically Fragile Regions, Guilin 541004, China. Electronic address:
A new nanopolypropylene (PP) surface molecularly imprinted polyacrylamide (PP@MIP) probe was synthesized facilely for the Resonance Rayleigh Scattering (RRS) determination of trace sulfadiazine (SDZ), using PP as nanosubstrate, SDZ as template molecule, and the acrylamide as functional monomer. The catalytic effect of PP@MIP on the reduction of HAuCl by hydrazine hydrate to form AuNP, a nano-indicated reaction, was investigated. The generated AuNPs had a strong RRS effect, and the addition of SDZ resulted in the selective formation of PP@MIP-SDZ complex, which further promoted the generation of AuNP and increased the RRS signal.
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