AI Article Synopsis
- The study aimed to explore how the relationship between SARS-CoV2 viral load (VL) and inflammation markers changes over time in hospitalized COVID-19 patients and if these markers can predict severe health outcomes.
- Researchers collected samples from 160 patients and found that higher levels of specific inflammatory markers at admission were linked to severe outcomes, while the association between VL and inflammation markers strengthened in the days following hospitalization.
- The findings suggest that certain inflammatory markers, particularly when combined with high VL, could help identify severe cases, leading to potential changes in treatment approaches that use both antiviral and anti-inflammatory strategies.
Article Abstract
Objectives: To investigate temporal changes in the association between SARS-CoV2 viral load (VL) and markers of inflammation during hospitalization, as well as the ability of these markers alone or in combination to predict severe outcomes.
Methods: Serial oropharyngeal and blood samples were obtained from hospitalized COVID-19 patients (n = 160). Levels of inflammatory markers and oropharyngeal VL were measured during hospitalization (admission, days 3-5, and days 7-10) and related to severe outcomes (respiratory failure/intensive care unit admission).
Results: Elevated admission levels of IL (interleukin)-6, IL-33, IL-8, monocyte chemoattractant protein-1 (MCP-1), interferon-γ-induced protein 10 (IP-10), IL-1β, and IL-1Ra were associated with severe outcomes during hospitalization. Although no inflammatory markers correlated with VL at baseline, there was a significant correlation between VL and levels of IP-10 and MCP-1 at days 3-5, accompanied by IL-8 and IL-6 at days 7-10. Finally, there was a seemingly additive effect of IP-10, MCP-1, and IL-6 in predicting severe outcomes when combined with high VL at baseline.
Conclusions: An increasing number of inflammatory markers were associated with VL during the first 10 days of hospitalization, and several of these markers were associated with severe outcomes, in particular when combined with elevated VL. Future studies should assess the potential for combining antiviral and immunomodulatory treatment, preferably guided by viral and inflammatory biomarkers, for the selection of high-risk patients.
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| http://dx.doi.org/10.1111/joim.13820 | DOI Listing |
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