AI Article Synopsis

  • People with COVID-19 who need special breathing support called ECMO often have problems related to their brain's blood flow regulation.
  • A study looked at 48 patients, some with COVID-19 and some without, to see how their brains were affected.
  • It was found that patients with COVID-19 had more trouble with brain blood flow regulation compared to those without the virus.

Article Abstract

Introduction: Cerebrovascular complications are feared but also commonly reported in patients with COVID-19 requiring extracorporeal membrane oxygenation (ECMO) support therapy. Besides other reasons, a connection between impaired cerebral autoregulation and SARS-CoV-2 infection as a mechanism for an increase in cerebrovascular complications has been hypothesized.

Methods: In an observational single-center study, we investigated a cohort of 48 patients requiring veno-venous ECMO support therapy with ( = 31) and without SARS-CoV-2 infection ( = 17). Cerebral autoregulation was assessed with the cerebral oximetry-derived autoregulation index (ORx) based on a moving correlation between arterial pressure and cerebral oximetry.

Results: Patients with ECMO support therapy and SARS-CoV-2 experienced more time with impaired cerebral autoregulation than without SARS-CoV-2 [17 ± 9 vs. 13 ± 9% ( = 0.027)]. Patients with SARS-CoV-2 suffering from cerebrovascular complications had more time with impaired autoregulation than non SARS-CoV-2 patients with these complications (19 ± 9 vs. 10 ± 4%,  = 0.032).

Conclusion: Our results suggest a connection between SARS-CoV-2 and impaired cerebral autoregulation as well as cerebrovascular complications in SARS-CoV-2 patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246866PMC
http://dx.doi.org/10.3389/fmed.2024.1423241DOI Listing

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