AI Article Synopsis
- Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major cause of hospital-acquired pneumonia and shows multidrug resistance, especially in intensive care units.
- A study of 187 sputum samples found that CRKP isolates showed a high resistance rate to various antibiotics, while colistin and tigecycline were the most effective treatments.
- Combining solithromycin with meropenem and cefotaxime demonstrated strong synergistic effects, suggesting these combinations could be effective alternatives for treating infections caused by MDR CRKP.
Article Abstract
is considered as the most common pathogen of hospital-acquired pneumonia. has emerged as the superbug which had shown multidrug resistance (MDR) as well as extensively drug resistance. Carbapenem resistant (CRKP) has become a menace for the treatment with monotherapy of the patients mainly admitted in intensive care units. Hence, in the present study we collected total 187 sputum isolates of and performed the antimicrobial susceptibility testing by using the automated Vitek-2 system and broth micro-dilution method (67 CRKP). The combination study of solithromycin with meropenem, colistin, cefotaxime, piperacillin and tazobactam, nitrofurantoin, tetracycline, levofloxacin, curcumin and nalidixic acid was performed by using checkerboard assay. We observed the high rate of resistance towards ampicillin, cefotaxime, ceftriaxone, cefuroxime and aztreonam. The colistin and tigecycline were the most sensitive drugs. The CRKP were 36%, maximum were from the patients of ICUs. The best synergistic effect of solithromycin was with meropenem and cefotaxime (100%), colistin and tetracycline (80%). So, these combinations can be a choice of treatment for the infections caused by MDR CRKP and other Gram-negative bacteria where the monotherapy could not work.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246330 | PMC |
| http://dx.doi.org/10.1007/s12088-024-01188-8 | DOI Listing |
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