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Fluorinated Titanium Oxide (TiOF) Nanospindles as Ultrasound-Triggered Pyroptosis Inducers to Boost Sonodynamic Immunotherapy. | LitMetric

Fluorinated Titanium Oxide (TiOF) Nanospindles as Ultrasound-Triggered Pyroptosis Inducers to Boost Sonodynamic Immunotherapy.

ACS Nano

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China.

Published: July 2024

AI Article Synopsis

  • Pyroptosis is a type of programmed cell death triggered by the immune system and can be initiated by reactive oxygen species (ROS), which play a key role in fighting cancer cells.
  • Sonodynamic therapy (SDT) utilizing fluorinated titanium oxide (TiOF) sonosensitizers shows promise for inducing pyroptosis in cancer cells through ultrasound, enhancing the effectiveness of the immune response.
  • The structural modifications of TiOF improve its capabilities to generate ROS under ultrasound stimulation, leading to significant mitochondrial damage in cancer cells, suppressing tumor growth, and promoting lasting immune memory to prevent tumor recurrence.

Article Abstract

Pyroptosis is an inflammatory form of programmed cell death associated with the immune system that can be induced by reactive oxygen species (ROS). As a therapeutic strategy with better penetration depth, sonodynamic therapy (SDT) is expected to induce pyroptosis of cancer cells and boost the immune response. However, it is still a limited problem to precisely adjust the structure of sonosensitizers to exhibit satisfactory sono-catalytic properties. Herein, fluorinated titanium oxide (TiOF) sonosensitizers were developed to induce pyroptosis under ultrasound (US) to boost antitumor immune responses, enabling highly effective SDT. On the one hand, the introduction of F atoms significantly reduced the adsorption energy of TiOF for oxygen and water, which is conducive to the occurrence of sono-catalytic reactions. On the other hand, the process of F replacing O increased the oxygen vacancies of the sonosensitizer and shortened the band gap, which enabled powerful ROS generation ability under US stimulation. In this case, large amounts of ROS could effectively kill cancer cells by inducing mitochondrial damage and disrupting oxidative homeostasis, leading to significant cell pyroptosis. Moreover, SDT treatment with TiOF not only suppressed tumor proliferation but also elicited robust immune memory effects and hindered tumor recurrence. This work highlighted the importance of precisely regulating the structure of sonosensitizers to achieve efficient ROS generation for inducing pyroptosis, which sets the stage for the further development of SDT-immunotherapy.

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Source
http://dx.doi.org/10.1021/acsnano.4c05448DOI Listing

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