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| http://dx.doi.org/10.1007/s13181-024-01017-w | DOI Listing |
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Glutathione, Vitamin C, and Cysteine Use in Autistic Children With Disruptive Behavior: A Double-Blind, Placebo-Controlled Crossover Pilot Study.
J Dev Behav Pediatr
January 2025
Department of Pediatrics and Norton Children's Research Institute, School of Medicine, University of Louisville, Louisville, KY.
Objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by social communication differences and restricted interests. One proposed biologic mechanism underlying ASD is oxidative stress, leading to the clinical use of glutathione based on anecdotal reports of improved behavior in autistic children. In this pilot study, we tested this observation using a randomized clinical trial format to collect preliminary data on glutathione safety and efficacy.
View Article and Find Full Text PDFA randomized, clinical trial of intravenous N-acetylcysteine as an antioxidant therapy in acute organophosphorus pesticide poisoning.
Toxicol Res (Camb)
January 2025
Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo 1181, Egypt.
The incidence of acute organophosphate (OP) poisoning has steadily increased in developing countries. Many studies showed that oxidative stress could have a significant role in its mechanism. The current study aimed to evaluate the role of N acetylcysteine (NAC) as an antioxidant in acute OP poisoned.
View Article and Find Full Text PDFLiver failure after food poisoning, an under-recognized entity: A case report.
World J Hepatol
November 2024
Department of Gastroenterology and Hepatology, Geneva University Hospitals, Geneva 1205, Switzerland.
Article Synopsis
- Foodborne illnesses can lead to serious conditions like liver failure, especially in vulnerable populations such as children and young adults, but they often go unreported due to their self-limiting nature.
- In a specific case, a 48-year-old woman experienced severe symptoms after eating contaminated rice salad, resulting in metabolic acidosis and liver dysfunction.
- After treatment in the emergency department, including the use of N-acetylcysteine, her condition improved, and she was discharged nine days later with recovering liver function.
High-dose Intravenous N-Acetylcysteine in Mechanically Ventilated Patients with COVID-19 Pneumonia: A Propensity-Score Matched Cohort Study.
J Intensive Care Med
November 2024
Intensive Care Unit, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong.
Article Synopsis
- Current severe COVID-19 treatments have side effects, and N-acetylcysteine (NAC) is being explored as a safer alternative, though research on its effectiveness in critical cases is limited.
- A study analyzed data from patients over 18 in ICU with respiratory failure and found that those receiving high-dose NAC (10 g/day) had higher 28-day mortality and fewer ventilator-free days compared to those who did not.
- After adjusting for variables, the matched analysis showed no significant impact of NAC on 28-day mortality rates or recovery metrics, suggesting it may not be an effective treatment for severe COVID-19 pneumonia.*
Changes in Resting-State Functional Connectivity and Cognitive-Affective Symptoms in Patients With Post-Concussion Syndrome Treated With N-Acetyl Cysteine.
J Head Trauma Rehabil
November 2024
Author Affiliations: Department of Integrative Medicine and Nutritional Sciences, Marcus Institute of Integrative Health, Thomas Jefferson University, Philadelphia, PA (Drs Monti and Zabrecky, Ms Wintering, and Drs Bazzan and Newberg); and Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA (Ms Vedaei and Drs Alizadeh, Mohamed, and Newberg).
Article Synopsis
- Concussion is a major cause of traumatic brain injury, with many patients experiencing long-term symptoms known as chronic post-concussion syndrome (PCS), affecting 10% to 50% of those injured.
- This study aimed to evaluate the effectiveness of N-acetylcysteine (NAC), an antioxidant, in improving symptoms in patients with persistent PCS over three months.
- Results showed significant symptom improvements and changes in brain connectivity in patients treated with NAC compared to those receiving standard care, suggesting NAC may offer a beneficial treatment option for chronic PCS.
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