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Thermomagneto-responsive injectable hydrogel for chondrogenic differentiation of mesenchymal stem cells.
Biomater Adv
March 2025
Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, P.O. Box 14115-154, Iran; Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, P.O. Box 14115-154, Iran.
Article Synopsis
- Damaged cartilage has poor self-healing capabilities, which necessitates the development of innovative tissue engineering techniques like injectable hydrogels that mimic cartilage properties.
- The study explores a newly designed injectable hydrogel embedded with magnetic iron oxide nanoparticles (MNPs) that promote the differentiation of stem cells into cartilage-forming cells when exposed to a magnetic field.
- Results show that hydrogels with MNPs exhibit improved mechanical properties, enhanced cell viability and adhesion, and promote chondrogenic differentiation more effectively than without MNPs, indicating potential for advanced tissue engineering applications.
A magneto-mechanical genetics toolbox for in vivo neuromodulation.
Nat Nanotechnol
September 2024
Instituto de Neurociencias CSIC-UMH, Avenida Santiago Ramon y Cajal, San Juan de Alicante, Spain.
Nanoscale Magneto-mechanical-genetics of Deep Brain Neurons Reversing Motor Deficits in Parkinsonian Mice.
Nano Lett
January 2024
Center for Nanomedicine, Institute for Basic Science, Seoul 03722, Republic of Korea.
Here, we introduce the magneto-mechanical-genetic (MMG)-driven wireless deep brain stimulation (DBS) using magnetic nanostructures for therapeutic benefits in the mouse model of Parkinson's disease (PD). Electrical DBS of the subthalamic nucleus (STN) is an effective therapy for mitigating Parkinson's motor symptoms. However, its broader application is hampered by the requirement for implanted electrodes and the lack of anatomical and cellular specificity.
View Article and Find Full Text PDFMagnetic Control of Protein Expression via Magneto-mechanical Actuation of ND-PEGylated Iron Oxide Nanocubes for Cell Therapy.
ACS Appl Mater Interfaces
April 2023
Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
Engineered cells used as smart vehicles for delivery of secreted therapeutic proteins enable effective treatment of cancer and certain degenerative, autoimmune, and genetic disorders. However, current cell-based therapies use mostly invasive tools for tracking proteins and do not allow for controlled secretion of therapeutic proteins, which could result in unconstrained killing of surrounding healthy tissues or ineffective killing of host cancer cells. Regulating the expression of therapeutic proteins after success of therapy remains elusive.
View Article and Find Full Text PDFMagneto mitochondrial dysfunction mediated cancer cell death using intracellular magnetic nano-transducers.
Biomater Sci
August 2021
Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA. and Department of Biomedical Engineering, McCormick School of Engineering, Evanston, IL 60208, USA and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA.
Mitochondria are crucial regulators of the intrinsic pathway of cancer cell death. The high sensitivity of cancer cells to mitochondrial dysfunction offers opportunities for emerging targets in cancer therapy. Herein, magnetic nano-transducers, which convert external magnetic fields into physical stress, are designed to induce mitochondrial dysfunction to remotely kill cancer cells.
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