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Distinct network patterns emerge from Cartesian and XOR epistasis models: a comparative network science analysis.
BioData Min
December 2024
School of Computing, Queen's University, 557 Goodwin Hall, 21-25 Union St, Kingston, K7L 2N8, Ontario, Canada.
Background: Epistasis, the phenomenon where the effect of one gene (or variant) is masked or modified by one or more other genes, significantly contributes to the phenotypic variance of complex traits. Traditionally, epistasis has been modeled using the Cartesian epistatic model, a multiplicative approach based on standard statistical regression. However, a recent study investigating epistasis in obesity-related traits has identified potential limitations of the Cartesian epistatic model, revealing that it likely only detects a fraction of the genetic interactions occurring in natural systems.
View Article and Find Full Text PDFRAIN: Reconstructed-aware in-context enhancement with graph denoising for session-based recommendation.
Neural Netw
December 2024
Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, 100190, China; Key Laboratory of Network Information System Technology (NIST), Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100190, China; School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, 100190, China.
Session-based recommendation aims to recommend the next item based on short-term interactions. Traditional session-based recommendation methods assume that all interacted items are closely related to the user's interests. However, noise (e.
View Article and Find Full Text PDFAnalysis of posterior hip joint impingement about developmental dysplasia of the hip after total hip arthroplasty.
Clin Biomech (Bristol)
December 2024
Department of Orthopedic Surgery, Hiroshima University Hospital Graduate School of Biomedical and Health Sciences, Hiroshima City, Hiroshima Prefecture, Japan.
Background: Total hip arthroplasty is the preferred treatment for advanced hip osteoarthritis, yet complications like hip dislocation (0.2 %-10 %) persist due to factors such as implant design, positioning, surgical technique, and patient-specific conditions. Impingement between prosthetic components or the acetabulum and proximal femur is a primary cause of instability.
View Article and Find Full Text PDFRevolutionising Cancer Immunotherapy: Advancements and Prospects in Non-Viral CAR-NK Cell Engineering.
Cell Prolif
December 2024
Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
The recent advancements in cancer immunotherapy have spotlighted the potential of natural killer (NK) cells, particularly chimeric antigen receptor (CAR)-transduced NK cells. These cells, pivotal in innate immunity, offer a rapid and potent response against cancer cells and pathogens without the need for prior sensitization or recognition of peptide antigens. Although NK cell genetic modification is evolving, the viral transduction method continues to be inefficient and fraught with risks, often resulting in cytotoxic outcomes and the possibility of insertional mutagenesis.
View Article and Find Full Text PDFRecovery in soil carbon stocks but reduced carbon stabilization after near-natural restoration in degraded alpine meadows.
Sci Rep
December 2024
Grassland Technique Extension Station of Gansu Province, Lanzhou, 730000, Gansu, China.
Near-natural restoration is acknowledged as an effective strategy for enhancing soil organic carbon (SOC) sequestration in degraded grasslands. However, the alterations in SOC fractions, stability, and relative sequestration capacity after restoration of degraded alpine meadows remain uncertain. In this study, we utilized the degraded alpine meadows on the northeastern edge of the Tibetan Plateau as a research area, with grazing as the control (CK) and restoration of 20 years of banned grazing (BG) and growing season resting grazing (RG).
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