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Age-related macular degeneration (AMD) is one of the leading causes of blindness. AMD is currently incurable; the best solution is to prevent its occurrence. To develop drugs for AMD, it is crucial to have a model system that mimics the symptoms and mechanisms in patients. It is most important to develop safer and more effective anti-AMD drug. In this study, the dose of A2E and the intensity of blue light were evaluated to establish an appropriate atrophic in vitro model of AMD and anti-AMD effect and therapeutic mechanism of Codonopsis lanceolata. The experimental groups included a control group an AMD group treated with A2E and blue light, a lutein group treated with 25 μM lutein after AMD induction, and three groups treated with different doses of C. lanceolata (10, 20, and 50 μg/mL) after AMD induction. Intrinsic apoptotic pathway (Bcl-2 family), anti-oxidative system (Keap1/Nrf2/HO-1 antioxidant response element), and anti-carbonyl effect (4-hydroxynonenal [4-HNE]) were evaluated using immunofluorescence, MTT, TUNEL, FACS, and western blotting analyses. A2E accumulation in the cytoplasm of ARPE-19 cells depending on the dose of A2E. Cell viability of ARPE-19 cells according to the dose of A2E and/or blue light intensity. The population of apoptotic or necrotic cells increased based on the A2E dose and blue light intensity. Codonopsis lanceolata dose-dependently prevented cell death which was induced by A2E and blue light. The antiapoptotic effect of that was caused by activating Keap1/Nrf2/HO-1 pathway, suppressing 4-HNE, and modulating Bcl-2 family proteins like increase of antiapoptotic proteins such as Bcl-2 and Bcl-XL and decrease of proapoptotic protein such as Bim. Based on these findings, 30 μM A2E and 20 mW/cm blue light on adult retinal pigment epithelium-19 cells was an appropriate condition for AMD model and C. lanceolata shows promise as an anti-AMD agent.
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http://dx.doi.org/10.1038/s41598-024-67044-3 | DOI Listing |
BMC Genomics
December 2024
Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, No. 2888 Xincheng Street, Changchun , Jilin Province, 130118, China.
Background: Hericium coralloides is a traditional edible and medicinal mushroom. Light is a key factor in forming fruiting bodies of fungi; however, the effects of different light on the yield and morphogenesis of H. coralloides are still unknown.
View Article and Find Full Text PDFInorg Chem
December 2024
School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China.
In semiconductor catalysts, rational doping of nonmetallic elements holds significant scientific and technological importance for enhancing photocatalytic performance. Here, using a one-step hydrothermal technique, we synthesized iodine-doped BiOCl composite and evaluated the impact of iodine doping on its photocatalytic capability for organic dye degradation under visible light irradiation. In this study, we demonstrate that the introduction of iodide ions not only provides an ideal built-in electric field (BIEF) for BiOCl but also induces the generation of additional oxygen vacancies (OVs).
View Article and Find Full Text PDFConnect Tissue Res
December 2024
Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Aim: We aimed to investigate whether α-ketoglutarate (AKG) can promote autophagic activity under a peri-implant condition to enhance the osseointegration of dental implant in rats with osteoporosis (OP).
Methods: Con, Model and AKG groups were established for the random allocation of thirty rats ( = 10). Their bone metabolism indicators were measured.
FEBS J
December 2024
Department of Chemistry, The University of Manchester, Manchester Institute of Biotechnology, UK.
Photoreceptors control cellular processes in response to light. Most photoreceptors sense blue or red light, but the recent discovery of the cobalamin-dependent photoreceptor, CarH, has expanded the wavelength range of photoreception to other regions of the electromagnetic spectrum to include the green light region. Further identification of cobalamin-dependent green light-sensitive photoreceptors has been hampered owing to poor annotation of the light responsiveness of cobalamin-binding domains (CBDs) in public databases.
View Article and Find Full Text PDFDalton Trans
December 2024
Organometallics and Materials Chemistry Lab, Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana, 502285, India.
Three 1-(anthracene-9-ylmethyl)-3-isopropyl-imidazol-2-thione Zn(II) halide complexes (1-3) and one 1-(anthracene-9-ylmethyl)-3-isopropyl-imidazol-2-selone Zn(II) dichloride complex (4) were synthesized and characterized. Complexes 2, 3, and 4 exhibited distorted tetrahedral geometries, while complex 1 adopted a regular tetrahedral geometry. All these complexes displayed emission in the crystalline state, with complex 3 emitting in the yellow region and complex 1 and 4 in the blue region, while complex 2 gave a bluish-green emission.
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