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| http://dx.doi.org/10.1136/bmjoq-2024-002785 | DOI Listing |
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Utilising primary care electronic health records to deliver the ALABAMA randomised controlled trial of penicillin allergy assessment.
Trials
October 2024
Leeds Institute of Medical Research, University of Leeds, Leeds, UK.
Background: Use of electronic health records (EHR) to provide real-world data for research is established, but using EHR to deliver randomised controlled trials (RCTs) more efficiently is less developed. The Allergy AntiBiotics And Microbial resistAnce (ALABAMA) RCT evaluated a penicillin allergy assessment pathway versus usual clinical care in a UK primary care setting. The aim of this paper is to describe how EHRs were used to facilitate efficient delivery of a large-scale randomised trial of a complex intervention embracing efficient participant identification, supporting minimising GP workload, providing accurate post-intervention EHR updates of allergy status, and facilitating participant follow up and outcome data collection.
View Article and Find Full Text PDFSpecification and de-labelling of unspecified allergic reactions to penicillins at a family medicine clinic.
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Improving antimicrobial stewardship with penicillin allergy testing: a review of current practices and unmet needs.
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bioMérieux, BioFire Diagnostics, Global Medical Affairs, 515 Colorow Drive, Salt Lake City, UT 84108, USA.
Penicillin allergy, the most frequently reported drug allergy, has been associated with suboptimal antibiotic therapy, increased antimicrobial resistance, increased rates of colonization and infection, as well as extended hospital length of stay and increased cost. Although up to 10% of all patients may report penicillin allergy, most penicillin allergies are not confirmed. As such, most patients with a penicillin allergy can still safely use penicillin and related drugs following a more precise assessment.
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