AI Article Synopsis
- GRAPPA's 2023 annual meeting showcased research from its pilot award program, focusing on advancements in understanding psoriatic arthritis (PsA).
- Key topics included identifying protein biomarkers linked to enthesitis, exploring gut microbial changes in PsA, and comparing single-cell profiles from synovial fluid and psoriatic skin lesions.
- Researchers also discussed how mechanotransduction may lead to the hyperactivation of transforming growth factor-β in the skin of psoriatic patients through αVβ6 integrin.
Article Abstract
Research progress from the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) pilot award program was presented and discussed at the GRAPPA 2023 annual meeting. Topics included identification of protein biomarkers associated with enthesitis in psoriatic arthritis (PsA), the role of on gut microbial dysbiosis in PsA, single-cell profiling of synovial fluid vs psoriatic skin lesions in PsA, and the role of mechanotransduction in hyperactivation of transforming growth factor-β via αVβ6 integrin in psoriatic epidermis.
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| http://dx.doi.org/10.3899/jrheum.2024-0292 | DOI Listing |
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