This paper reports a flexible glucose biosensor which is modified by a reduced-swelling and conductive zwitterionic hydrogel enzyme membrane that contains two forms of chemical cross-links. One chemical cross-linking is induced by thermal initiators and forms the basal network of the hydrogel. Another cross-linking is achieved by the coordination interactions between the multivalent metal ion Al and anionic group -COO of zwitterionic poly-carboxy betaine (pCBMA), which significantly increase the cross-linking density of the zwitterionic hydrogel, improving the reduced-swelling property and reducing the pore size. The better reduced-swelling property and reduced diameters of pores within the zwitterionic hydrogel make less glucose oxidase (GOx) leakage, thus significantly improving the enzyme membrane's service life. By introducing the Al and Cl, the conductivity of the zwitterionic hydrogel is enhanced approximately 10.4-fold. According to the enhanced conductivity, the reduced-swelling property, and the high GOx loading capacity of the zwitterionic hydrogel, the sensitivity of the biosensor with GOx/pCBMA-Al is significantly improved by 5 times and has a long service life. Finally, the proposed GOx/pCBMA-Al biosensor was applied in non-invasive blood glucose detection on the human body, verifying the capability in practice.
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http://dx.doi.org/10.1007/s00216-024-05429-z | DOI Listing |
Mater Today Bio
February 2025
Basic Research Key Laboratory of General Surgery for Digital Medicine, Affiliated Hospital of Hebei University, Baoding, 071000, China.
Achilles tendon is a motor organ that is prone to tissue adhesion during its repair process after rupture. Therefore, developing motion-responsive and anti-adhesive biomaterials is an important need for the repair of Achilles tendon rupture. Here, we report an injectable lubricative hydrogel (ILH) based on hydration lubrication mechanism, which is also motion-responsive based on sol-gel reversible transmission.
View Article and Find Full Text PDFMater Horiz
January 2025
College of Materials Science & Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
Developing hydrogels with high conductivity and toughness a facile strategy is important yet challenging. Herein, we proposed a new strategy to develop conductive hydrogels by growing metal dendrites. Water-soluble Sn ions were soaked into the gel and then converted to Sn dendrites an electrochemical reaction; the excessive Sn ions were finally removed by water dialysis, accompanied by dramatic shrinkage of the gel.
View Article and Find Full Text PDFTalanta
January 2025
Academy of Medical Engineering and Translational Medicine, Medical School, Tianjin University, Tianjin, 300072, China; School of Exercise and Health, Tianjin University of Sport, Tianjin, 300211, China. Electronic address:
Developing a wearable device that can continuously and reliably detect and evaluate heart rate variability (HRV) parameters is critical for the diabetic population with cardiac autonomic neuropathy (CAN). In this work, we proposed a zwitterionic conducting hydrogel that enabled a reliable and comfortable wearable device for the evaluation and detection of the autonomic nervous system (ANS). The hydrogel can achieve a strain of 2003 %, an electrical conductivity of 190 mS/m, and is capable of adhering to a variety of materials, including wood, plastic, and glass.
View Article and Find Full Text PDFAnal Chem
January 2025
Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, Ministry of Education; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China.
In marine environmental monitoring, due to the presence of a large number of interfering proteins and bacteria in seawater, it is of great significance to construct an efficient sensing interface with antifouling and antibacterial functions to avoid the aforementioned interferences. On this basis, the zwitterionic hydrogel based on sulfobetaine methacrylate (SBMA) and bovine serum albumin (BSA) was developed as an antifouling and antibacterial coating. The combination of hydration of zwitterions and hydrophilicity of hydrogels endows BSA@PSBMA with good antiadsorption ability, which effectively hinders the adhesion of proteins and bacteria, thereby improving the detection sensitivity of the biosensor.
View Article and Find Full Text PDFMater Today Bio
February 2025
Institution of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China.
Massive blood loss is the main cause of prehospital trauma-related death, the development of rapid and effective hemostatic materials is imminent. Injectable hydrogels have the advantages of covering irregular bleeding sites and quickly closing the wound. However, its inherent viscosity can easily precipitate tissue adhesion and other complications.
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