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Comparison of nylon, vicryl, and fibrin glue for nerve grafting in rats. | LitMetric

AI Article Synopsis

  • The study investigates the effectiveness of different suturing techniques (non-absorbable nylon, absorbable vicryl, and fibrin glue) in nerve grafting for rats with sciatic nerve injuries.
  • Results show that both vicryl and nylon sutures improved motor function significantly more than controls, with no major differences in nerve recovery overall among the different methods.
  • The findings suggest that vicryl sutures are equally effective as nylon sutures for nerve repair, challenging the previous notion that non-absorbable sutures are superior.

Article Abstract

Objectives: For nerve injuries, not amendable to tensionless epineural coaptation of the nerve, autografts are the preferred treatment. Although absorbable sutures are not recommended for nerve repair, there is no evidence that non-absorbable sutures are superior to absorbable sutures. This study aims to assess the effectiveness of non-absorbable monofilament nylon sutures, absorbable monofilament vicryl sutures, and fibrin glue when used for nerve grafting.

Methods: Lewis rats ( = 32) were subjected to a sciatic nerve transection and randomly assigned to a group: graft with Nylon, graft with Vicryl, graft with Fibrin Glue, or no graft. Motor function, sensory function, and thermal pain were assessed during a 12-week recovery period, and immunohistochemistry was used to assess macrophage response.

Results: At 12 weeks, the Vicryl and Nylon groups had significantly larger ankle angles at to lift off, which is a measure of motor function, compared to injured controls ( < 0.05). Grafted rats displayed no difference in thermal response but hypersensitivity to mechanical stimuli compared to the uninjured hindlimb. The Nylon, Vicryl, and Fibrin Glue groups all had significantly less atrophy of the gastrocnemius muscle compared to injured controls ( < 0.0001). In the Fibrin Glue group, 3/9 grafts did not incorporate. The Nylon group had significantly less ( = 0.0004) axon growth surrounding the suture holes compared to the Vicryl group. There were no differences in the axon counts, motor neurons, or sensory neurons between all grafted rats.

Conclusions: These results demonstrate that vicryl sutures work just as well as nylon for nerve recovery after injury and grafting.

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Source
http://dx.doi.org/10.1080/01616412.2024.2376307DOI Listing

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