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Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation.
Front Endocrinol (Lausanne)
January 2025
Department of Reproductive Medicine, Nanyang Central Hospital, Nanyang, China.
Objective: Several male factors have been reported to play a role in recurrent pregnancy loss (RPL). The aim of this study is to explore the relationship between semen parameters, sperm DNA fragmentation index (DFI) and RPL.
Method: A total of 1485 participants were recruited from a university hospital between April 2020 and August 2022.
Family planning and preimplantation testing: family experiences in congenital adrenal hyperplasia.
Front Endocrinol (Lausanne)
January 2025
Department of Endocrinology, Sydney Children's Hospital, Randwick, NSW, Australia.
Introduction: Pre-implantation testing (PGT) is often suggested by healthcare professionals (HCP) to parents of children with congenital adrenal hyperplasia (CAH) considering subsequent children. Despite this, some families choose to conceive naturally without genetic testing and intervention. The aims of this study were to explore fertility choices of couples with a child with CAH and the decision making process and perceptions behind these choices, and to explore the families' lived experiences with CAH and the couples' subsequent fertility journey.
View Article and Find Full Text PDFAmmonia and hydrogen sulfide - new insights into gut microbiota and male infertility through meta-analysis.
Front Cell Infect Microbiol
January 2025
College of Environmental and Life Sciences, Murdoch University, Perth, WA, Australia.
Background: Ammonia (NH) and hydrogen sulfide (HS) are produced during digestion in the human gut, yet the impact of these internally generated gases on male reproduction have received limited attention in scientific research.
Methods: We systematically reviewed 935 scientific publications, spanning from 1947 to 2023, focusing on external or internal NH and/or HS, male infertility, and gut microbiota. Meta-analysis was conducted to evaluate the summary relative risk (RR) and 95% confidence intervals (CIs) of combined studies.
The application of machine learning approaches to classify and predict fertility rate in Ethiopia.
Sci Rep
January 2025
Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Integrating machine learning (ML) models into healthcare systems is a rapidly evolving field with the potential to revolutionize care delivery. This study aimed to classify fertility rates and identify significant predictors using ML models among reproductive women in Ethiopia. This study utilized eight ML models in 5864 reproductive-age women using Ethiopian Demographic Health Survey (EDHS), 2019 data.
View Article and Find Full Text PDFMuscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis.
Science
January 2025
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Myostatin is a paracrine myokine that regulates muscle mass in a variety of species, including humans. In this work, we report a functional role for myostatin as an endocrine hormone that directly promotes pituitary follicle-stimulating hormone (FSH) synthesis and thereby ovarian function in mice. Previously, this FSH-stimulating role was attributed to other members of the transforming growth factor-β family, the activins.
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