AI Article Synopsis
- Vocal fold scarring, caused by injury and inflammation, leads to voice hoarseness with limited treatment options that negatively impact quality of life.
- The study introduces a new injectable hydrogel embedded with microbeads that release an antifibrotic drug, pirfenidone, to help treat this condition effectively.
- The hydrogel demonstrates improved properties such as injectability and tissue compatibility, and successfully reduces fibroblast cell activity, indicating its potential use for vocal fold scarring treatment.
Article Abstract
Vocal fold (VF) scarring, a complex problem in laryngology, results from injury and inflammation of the layered architecture of the VFs. The resultant voice hoarseness, for which successful therapeutic options are currently limited, affects the patient's quality of life. A promising strategy to reverse this disorder is the use of antifibrotic drugs. The present study proposes a novel microbead-embedded injectable hydrogel that can sustain the release of the anti-fibrotic drug pirfenidone (PFD) for vocal fold scarring. Microbeads were developed using sodium alginate and gelatin, which were further embedded into a biomimetic and tissue adhesive gellan gum (GG) hydrogel. The microbead-embedded hydrogel exhibited improved injectability, viscoelasticity, tissue adhesiveness, degradability, and swelling compared to the hydrogel without beads. Additionally, the bead-embedded hydrogel could sustain the release of the PFD for a week. studies showed that the drug-loaded hydrogel could reduce the migration and proliferation of fibroblast cells in a dose-dependent manner. In summary, this study demonstrates the potential of a PFD-loaded injectable hydrogel with enhanced viscoelastic and tissue-adhesive properties for vocal fold scarring applications.
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| http://dx.doi.org/10.1021/acsabm.4c00422 | DOI Listing |
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