This research note examines historical trends in lifespan inequality and the intergenerational transmission of lifespan and longevity in the United States over the eighteenth, nineteenth, and twentieth centuries. We contribute to the literature by expanding the estimates of the familial component beyond parent-child associations to include multigenerational and horizontal classes of relatives of different sexes. We also examine how lifespan inequality and the role of the family in lifespan and longevity changed over time. We address the challenge of studying extended family networks in historical times by leveraging recent online crowdsourced genealogical data. Results confirm the presence of a familial component for all classes of relatives considered and highlight a stronger association for horizontal than for vertical relationships. Despite decreasing lifespan inequality, we find no evidence of decreased familial lifespan stratification throughout history. If anything, the results suggest a strengthening of the parent-child association. Finally, the results contribute to the debate on the representativeness and usability of crowdsourced genealogical data by emphasizing the importance of sample selection based on the quality of the information collected.
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http://dx.doi.org/10.1215/00703370-11458359 | DOI Listing |
Alzheimers Dement
December 2024
School of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Background: The role of circulating metabolome in cognitive impairment is limited and inconclusive. We aimed to identify plasma metabolites associated with cognitive impairment and evaluate the added predictive capacity of metabolite biomarkers on incident cognitive impairment beyond traditional risk factors.
Method: In the community-based Rugao Longevity and Ageing Study (RuLAS), plasma metabolome was profiled by nuclear magnetic resonance (NMR) spectroscopy.
Alzheimers Dement
December 2024
National University of Singapore, Singapore, Singapore, Singapore.
Background: Past studies examining sleep-cognition relationships mostly employed univariate approaches, which are subject to problems such as multicollinearity and multiple comparisons. Further, results from small sample univariate analyses are difficult to compare, precluding the identification of the aspects of sleep health associated with a particular cognitive domain(s). The current study used a multivariate approach to identify key sleep metrics and cognitive domains that contribute to the maximum sleep-cognition covariance in healthy older adults.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Background: SuperAgers-individuals age 80+ with episodic memory performance at least as good as those 20-30 years younger-provide a unique perspective on cognitive resilience and resistance in aging. The SuperAging Research Initiative (SRI), spearheaded by The University of Chicago and involving multiple academic partners, investigates factors underpinning robust cognitive aging. One key SRI project, leverages a fully remote data collection paradigm to: 1) discern activity patterns that characterize SuperAgers and 2) explore the 'complexity hypothesis in aging'-whether dynamic physiological responsiveness is a hallmark of exceptional cognitive aging.
View Article and Find Full Text PDFBackground: The Adult Changes in Thought (ACT) study is an ongoing population-based prospective cohort study that began in 1994 and aims to identify risk and preventive factors for dementia. ACT randomly selects and enrolls Kaiser Permanente Washington (KPWA) health plan members age ≥ 65 years. Historically, the cohort make up has been 88% non-Hispanic White participants.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Background: Due to declining birthrate and increasing longevity, the number of older people living alone with cognitive impairment is rapidly increasing in Japan. They have a lot of challenges in terms of health, housing, finance, daily life and protection of rights, all of which should be clarified to create inclusive, equitable, and sustainable super-aged societies.
Methods: A series of factual investigation was conducted using existing statical materials, community-based epidemiological studies, clinic-based case studies, and literature reviews.
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