AI Article Synopsis
- Current surgical treatments for intracerebral hemorrhage (ICH) save lives, but high lethality and disability rates remain due to individual patient differences and limited postoperative improvement.
- The review outlines the mechanisms of ICH, highlighting primary and secondary injuries like inflammation and edema, and evaluates existing treatments and their shortcomings.
- It also explores recent advancements in biomaterials, such as nanomaterials and hydrogels, and discusses their potential challenges and future applications in ICH therapy.
Article Abstract
Although the current surgical hematoma removal treatment saves patients' lives in critical moments of intracerebral hemorrhage (ICH), the lethality and disability rates of ICH are still very high. Due to the individual differences of patients, postoperative functional improvement is still to be confirmed, and the existing drug treatment has limited benefits for ICH. Recent advances in biomaterials may provide new ideas for the therapy of ICH. This review first briefly describes the pathogenic mechanisms of ICH, including primary and secondary injuries such as inflammation and intracerebral edema, and briefly describes the existing therapeutic approaches and their limitations. Secondly, existing nanomaterials and hydrogels for ICH, including exosomes, liposomes, and polymer nanomaterials, are also described. In addition, the potential challenges and application prospects of these biomaterials for clinical translation in ICH treatment are discussed.
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