AI Article Synopsis
- Prussian blue effectively treats radiocaesium and thallium poisoning, with its nanoparticles (PBNPs) showing promise in binding radioactive thallium for nuclear medicine.
- Understanding the interaction between thallium and PBNPs is key to enhancing their performance and stability in medical applications.
- This study reveals that thallium ions can significantly alter the ionic composition of PBNPs without compromising their structural integrity, paving the way for tailored designs in nuclear medicine.
Article Abstract
Prussian blue is known for its high affinity for thallium and other univalent metal cations and has been used as a treatment for radiocaesium and thallium/radiothallium poisoning. While Prussian blue nanoparticles (PBNPs) show potential for binding radioactive thallium for further use in nuclear medicine applications, the inclusion mechanism remains elusive. Understanding the interaction between PBNPs and Tl is essential for identifying the physicochemical and radiochemical properties required for optimal performance. In this work, we evaluated the binding mechanism between Tl and PBNPs with different coatings and core shapes. Combining PBNPs with [Tl] thallium(I) chloride provided high radiolabelling yields and radiochemical stabilities under physiological conditions. Comprehensive characterisation by different X-ray techniques confirmed that Tl ions are located in the interstitial sites within the crystal structure, maintaining the integrity of the iron (Fe) 4p electronic distribution and inducing local modifications in the nearby C-N ligands. Additionally, this inclusion does not impact the core or the shell of the nanoparticles but does alter their ionic composition. The PB ionic network undergoes significant changes, with a substantial drop in K content, confirming that Tl ions replace K and occupy additional spaces within the crystal structure. These results open new opportunities in nuclear medicine applications with Tl-PBNPs where the size, shape and composition of the particles can be specifically tuned depending on the desired biological properties without affecting the radiochemical performance as a vehicle for Tl.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340343 | PMC |
| http://dx.doi.org/10.1039/d4tb01203h | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rapid and receptor-free Prussian blue electrochemical sensor for the detection of pathogenic bacteria in blood.
Bioelectrochemistry
January 2025
Department of Mechanical Engineering, Ajou University, South Korea. Electronic address:
Bloodstream bacterial infections, a major health concern due to rising sepsis rates, require prompt, cost-effective diagnostics. Conventional methods, like CO-based transduction, face challenges such as volatile metabolites, delayed gas-phase signaling, and the need for additional instruments, whereas electrochemical sensors provide rapid, sensitive, and efficient real-time detection. In this study, we developed a bioreceptor-free Prussian blue (PB) sensor platform for real-time bacterial growth monitoring in blood culture.
View Article and Find Full Text PDFA novel electrochemiluminescence sensor based on NiCo NCs@CN QDs nanocomposites with poly-L-cysteine as co-reaction accelerator for ultrasensitive detection of vitamin K.
Food Chem
January 2025
State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, 29 The Thirteenth Road, Tianjin Economy and Technology Development Area, Tianjin 300457, PR China; Research Institute of Food Crops, Xinjiang Academy of Agricultural Sciences, No.403 Nanchang Road, Urumqi, Xinjiang 830091, PR China. Electronic address:
Article Synopsis
- A new eco-friendly electrochemiluminescence (ECL) sensor using carbon quantum dots (CN QDs) was developed for highly sensitive detection of vitamin K (VK).
- The sensor combined nickel-cobalt nanocages (NiCo NCs) with CN QDs, enhancing luminescent properties and allowing for efficient signal amplification when applied to a poly-L-cysteine film.
- It demonstrated a detection range for VK between 1.0 × 10⁻⁸ to 5.0 × 10⁻⁴ mol/L, with a low limit of detection at 1.65 × 10⁻⁹ mol/L, and showed effective recoveries in food samples, indicating its practical application.
Modification of Cells with Metal Hexacyanoferrates for the Construction of a Yeast-Based Fuel Cell.
Molecules
January 2025
Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania.
This research presents a simple procedure for chemically modifying yeast () cells with nickel hexacyanoferrate (NiHCF) and ferric hexacyanoferrate, also known as Prussian blue (PB), to increase the conductivity of the yeast cell wall. Using linear sweep voltammetry, NiHCF-modified yeast and PB-modified yeast (NiHCF/yeast and PB/yeast, respectively) were found to have better cell wall conductivity in [Fe(CN)] and glucose-containing phosphate-buffered solution than unmodified yeast. Spectrophotometric analysis showed that the modification of yeast cells with NiHCF had a less harmful effect on yeast cell viability than the modification of yeast cells with PB.
View Article and Find Full Text PDFAn electrochemical immunosensing of electrochemically modified carbon cloth electrode based on functionalized gold nanoparticle-Prussian blue for the detection of aflatoxin B1 in vegetable oil industry.
Food Chem
January 2025
College of Food and Bioengineering, Xihua University, Chengdu 610039, China.
This study developed an electrochemical immunosensor for the detection of aflatoxin B1 (AFB1) in vegetable oil, based on an electrochemical modified carbon cloth (EMCC) electrode modified with a composite functional layer of cross-linked o-aminothiophenol functionalized AuNPs (o-ATP@AuNPs)/Prussian Blue (PB). The EMCC electrode substrate was prepared by modifying carbon cloth through electrochemical methods to increase its surface area, which allowed for the effective deposition of o-ATP@AuNPs/PB composite functional layer and improved the conductivity of the electrode material. The synergistic effect of o-ATP@AuNPs and PB significantly enhanced the sensitivity of the electrochemical sensor.
View Article and Find Full Text PDFPeroxidase (POD) Mimicking Activity of Different Types of Poly(ethyleneimine)-Mediated Prussian Blue Nanoparticles.
Nanomaterials (Basel)
December 2024
Diagnostic Nanotools Group, Hospital Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain.
Prussian blue nanoparticles (PBNPs) have been identified as a promising candidate for biomimetic peroxidase (POD)-like activity, specifically due to the metal centres (Fe/Fe) of Prussian blue (PB), which have the potential to function as catalytically active centres. The decoration of PBNPs with desired functional polymers (such as amino- or carboxylate-based) primarily facilitates the subsequent linkage of biomolecules to the nanoparticles for their use in biosensor applications. Thus, the elucidation of the catalytic POD mimicry of these systems is of significant scientific interest but has not been investigated in depth yet.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!