AI Article Synopsis
- Recent research on Orel and Luu leaf extracts shows promise for Alzheimer's treatment, revealing valuable chemical compositions and bioactivities.
- Various beneficial phytochemicals were identified, such as polyphenols and flavonoids, with HPLC-MS uncovering 23 significant compounds, including epicatechin gallate and quercetin.
- The ethanol extract demonstrated strong antioxidant and acetylcholinesterase (AChE) inhibition, improving memory and longevity in mice, suggesting potential applications in memory impairment therapies.
Article Abstract
Novel research on the chemical compositions and biochemical activities of Orel and Luu leaf extracts revealed valuable resources with potential applications in Alzheimer's disease treatment. Qualitative phytochemicals detected various compound groups, including polyphenols, saponins, tannins, flavonoids, alkaloids, amino acids, coumarins, and polysaccharides. HPLC-MS identified 23 compounds in leaves with compounds found at significant levels, including epicatechin gallate (17.12%), tryptophan (13.73%), isovitexin (12.91%), gallic acid (3.06%), and quercetin (3.06%). Interestingly, the ethanol extract (CLL-Ew) exhibited the highest extraction yield (26.6%) and potent antioxidant and acetylcholinesterase (AChE) inhibitory effects in vitro. In the model, CLL-Ew improved longevity, movement, and memory by reducing malondialdehyde and increasing glutathione levels. Docking simulations suggested that the above compounds bind tightly to AChE's active site, potentially contributing to memory enhancement. Interestingly, observations of male and female mice after administration of a dose of 5000 mg/kg leaf extract were recorded normally throughout the 14 day experiment. These findings highlight the potential of leaf extracts in functional foods and therapeutic interventions for memory impairment prevention and treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11238292 | PMC |
| http://dx.doi.org/10.1021/acsomega.4c02980 | DOI Listing |
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